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Fish oil delays lym...
Fish oil delays lymphoma progression in the TLL mouse
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- Johansson, Ann-Sofie (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Norén-Nyström, Ulrika (författare)
- Umeå universitet,Pediatrik
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- Larefalk, Åsa (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Holmberg, Dan (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Lindskog, Magnus (författare)
- Uppsala universitet,Karolinska Institutet,Enheten för onkologi,Klinisk farmakologi
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(creator_code:org_t)
- 2010-10-04
- 2010
- Engelska.
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 51:11, s. 2092-2097
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The objective was to investigate the effects of omega-3 fatty acids, known for their anti-inflammatory effects, on time to lymphoma progression and survival in the TLL mouse, a strain genetically prone to developing aggressive T-cell lymphoma. Compared to mice fed a standard diet, TLL mice fed omega-3 (menhaden fish oil) experienced a significant delay in disease progression and were more likely to remain alive and symptom free during the first 8 months of the study. In contrast, omega-6 supplementation (corn oil) did not significantly affect lymphoma progression. Irrespective of diet, all mice eventually progressed, and 1-year survival was not different between the groups. Immunological analysis demonstrated a significantly altered B-cell compartment and fewer NK cells in healthy C57Black6 mice fed omega-3, compared to controls. In conclusion, a diet rich in omega-3 fatty acids delays lymphoma development in the TLL mouse possibly by mechanisms that include complex effects on immune function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- T-cell lymphoma
- mouse
- fish oil
- omega-3
- immunity
- MEDICINE
- MEDICIN
- medicinsk genetik
- Medical Genetics
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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