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E2F activation of S...
E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.
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Tyagi, Shweta (författare)
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- Chabes, Anna Lena (författare)
- Center for Integrative Genomics, University of Lausanne, Switzerland
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Wysocka, Joanna (författare)
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Herr, Winship (författare)
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(creator_code:org_t)
- Elsevier (Cell Press), 2007
- 2007
- Engelska.
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Ingår i: Molecular Cell. - : Elsevier (Cell Press). - 1097-2765 .- 1097-4164. ; 27:1, s. 107-119
- Relaterad länk:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle progression, particularly the S phase. E2F proteins repress transcription in association with retinoblastoma pocket proteins, but less is known about how they activate transcription. Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in insect cells. Human HCF-1-E2F interactions are versatile: their associations and binding to E2F-responsive promoters are cell-cycle selective, and HCF-1 displays coactivator properties when bound to the E2F1 activator and corepressor properties when bound to the E2F4 repressor. During the G1-to-S phase transition, HCF-1 recruits the mixed-lineage leukemia (MLL) and Set-1 histone H3 lysine 4 methyltransferases to E2F-responsive promoters and induces histone methylation and transcriptional activation. These results suggest that HCF-1 induces cell-cycle-specific transcriptional activation by E2F proteins to promote cell proliferation.
Nyckelord
- DNA
- Cellcycle
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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