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Tumor necrosis fact...
Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk : the EPIC study
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- Dossus, Laure (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Becker, Susen (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Rinaldi, Sabina (författare)
- Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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- Lukanova, Annekatrin (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Tjønneland, Anne (författare)
- Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
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- Olsen, Anja (författare)
- Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
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- Overvad, Kim (författare)
- Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
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- Chabbert-Buffet, Nathalie (författare)
- Department of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France
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- Boutron-Ruault, Marie-Christine (författare)
- INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
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- Clavel-Chapelon, Françoise (författare)
- INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
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- Teucher, Birgit (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Pischon, Tobias (författare)
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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- Boeing, Heiner (författare)
- Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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- Trichopoulou, Antonia (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
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- Benetou, Vasiliki (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
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- Valanou, Elisavet (författare)
- Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
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- Palli, Domenico (författare)
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
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- Sieri, Sabina (författare)
- Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy
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- Sacerdote, Carlotta (författare)
- Center for Cancer Prevention (CPO Piedmont), Turin, Italy
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- Galasso, Rocco (författare)
- Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy
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- Redondo, Maria-Luísa (författare)
- Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain
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- Bonet Bonet, Catalina (författare)
- Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
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- Molina-Montes, Esther (författare)
- Andalusian School of Public Health, Granada, Spain
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- Altzibar, Jone M (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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- Chirlaque, Maria-Dolores (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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- Ardanaz, Eva (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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- Bueno-de-Mesquita, H Bas (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
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- van Duijnhoven, Fränzel J B (författare)
- National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
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- Peeters, Petra H M (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
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- Onland-Moret, N Charlotte (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
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- Lundin, Eva (författare)
- Umeå universitet,Patologi
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- Idahl, Annika (författare)
- Umeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin
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- Khaw, Kay-Tee (författare)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Wareham, Nicholas (författare)
- MRC Epidemiology Unit, Cambridge, United Kingdom
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- Allen, Naomi (författare)
- Nuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
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- Romieu, Isabelle (författare)
- International Agency for Research on Cancer, Lyon, France
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- Fedirko, Veronika (författare)
- International Agency for Research on Cancer, Lyon, France
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- Hainaut, Pierre (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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- Romaguera, Dora (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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- Norat, Teresa (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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- Riboli, Elio (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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(creator_code:org_t)
- 2011-03-08
- 2011
- Engelska.
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Ingår i: International Journal of Cancer. - Geneve : International union against cancer. - 0020-7136 .- 1097-0215. ; 129:8, s. 2032-2037
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- tumor necrosis factor (TNF)-α
- soluble TNF receptors
- inflammation
- endometrial cancer
- prospective
- MEDICINE
- MEDICIN
- Pathology
- patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Dossus, Laure
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Becker, Susen
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Rinaldi, Sabina
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Lukanova, Anneka ...
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Tjønneland, Anne
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Olsen, Anja
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visa fler...
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Overvad, Kim
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Chabbert-Buffet, ...
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Teucher, Birgit
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Chang-Claude, Je ...
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Pischon, Tobias
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vasilik ...
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Valanou, Elisave ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Sacerdote, Carlo ...
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Galasso, Rocco
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Redondo, Maria-L ...
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Bonet Bonet, Cat ...
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Molina-Montes, E ...
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Altzibar, Jone M
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Chirlaque, Maria ...
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Ardanaz, Eva
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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Peeters, Petra H ...
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Onland-Moret, N ...
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Lundin, Eva
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Idahl, Annika
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Allen, Naomi
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Romieu, Isabelle
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Fedirko, Veronik ...
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Hainaut, Pierre
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Romaguera, Dora
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Norat, Teresa
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Riboli, Elio
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Kaaks, Rudolf
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