Sökning: onr:"swepub:oai:DiVA.org:umu-41629" > Tumor necrosis fact...
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000 | 09182naa a2200925 4500 | |
001 | oai:DiVA.org:umu-41629 | |
003 | SwePub | |
008 | 110330s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-416292 URI |
024 | 7 | a https://doi.org/10.1002/ijc.258402 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dossus, Laureu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
245 | 1 0 | a Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk :b the EPIC study |
264 | c 2011-03-08 | |
264 | 1 | a Geneve :b International union against cancer,c 2011 |
338 | a print2 rdacarrier | |
520 | a Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a tumor necrosis factor (TNF)-α | |
653 | a soluble TNF receptors | |
653 | a inflammation | |
653 | a endometrial cancer | |
653 | a prospective | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a Pathology | |
653 | a patologi | |
700 | 1 | a Becker, Susenu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Rinaldi, Sabinau Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Lukanova, Annekatrinu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Tjønneland, Anneu Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark4 aut |
700 | 1 | a Olsen, Anjau Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark4 aut |
700 | 1 | a Overvad, Kimu Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark4 aut |
700 | 1 | a Chabbert-Buffet, Nathalieu Department of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christineu INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France4 aut |
700 | 1 | a Clavel-Chapelon, Françoiseu INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France4 aut |
700 | 1 | a Teucher, Birgitu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Pischon, Tobiasu Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany4 aut |
700 | 1 | a Boeing, Heineru Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany4 aut |
700 | 1 | a Trichopoulou, Antoniau Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece4 aut |
700 | 1 | a Benetou, Vasilikiu Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece4 aut |
700 | 1 | a Valanou, Elisavetu Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece4 aut |
700 | 1 | a Palli, Domenicou Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy4 aut |
700 | 1 | a Sieri, Sabinau Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy4 aut |
700 | 1 | a Tumino, Rosariou Cancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy4 aut |
700 | 1 | a Sacerdote, Carlottau Center for Cancer Prevention (CPO Piedmont), Turin, Italy4 aut |
700 | 1 | a Galasso, Roccou Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy4 aut |
700 | 1 | a Redondo, Maria-Luísau Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain4 aut |
700 | 1 | a Bonet Bonet, Catalinau Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain4 aut |
700 | 1 | a Molina-Montes, Estheru Andalusian School of Public Health, Granada, Spain4 aut |
700 | 1 | a Altzibar, Jone Mu CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut |
700 | 1 | a Chirlaque, Maria-Doloresu CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut |
700 | 1 | a Ardanaz, Evau CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut |
700 | 1 | a Bueno-de-Mesquita, H Basu CIBER de Epidemiología y Salud Pública (CIBERESP), Spain4 aut |
700 | 1 | a van Duijnhoven, Fränzel J Bu National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands4 aut |
700 | 1 | a Peeters, Petra H Mu Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands4 aut |
700 | 1 | a Onland-Moret, N Charlotteu Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands4 aut |
700 | 1 | a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001 |
700 | 1 | a Idahl, Annikau Umeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)anid0002 |
700 | 1 | a Khaw, Kay-Teeu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut |
700 | 1 | a Wareham, Nicholasu MRC Epidemiology Unit, Cambridge, United Kingdom4 aut |
700 | 1 | a Allen, Naomiu Nuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Romieu, Isabelleu International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Fedirko, Veronikau International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Hainaut, Pierreu Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut |
700 | 1 | a Romaguera, Dorau Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut |
700 | 1 | a Norat, Teresau Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut |
700 | 1 | a Riboli, Eliou Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom4 aut |
700 | 1 | a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
710 | 2 | a Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germanyb Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France4 org |
773 | 0 | t International Journal of Cancerd Geneve : International union against cancerg 129:8, s. 2032-2037q 129:8<2032-2037x 0020-7136x 1097-0215 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.25840 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-41629 |
856 | 4 8 | u https://doi.org/10.1002/ijc.25840 |
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