Sökning: onr:"swepub:oai:DiVA.org:umu-42549" > Novel prognostic su...
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000 | 04155naa a2200685 4500 | |
001 | oai:DiVA.org:umu-42549 | |
003 | SwePub | |
008 | 110408s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-425492 URI |
024 | 7 | a https://doi.org/10.1182/blood-2009-04-2151522 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Balgobind, Brian V4 aut |
245 | 1 0 | a Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia :b results of an international retrospective study. |
264 | 1 | b American Society of Hematology,c 2009 |
338 | a print2 rdacarrier | |
520 | a Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is involved, and more than 50 translocation partners have been described. Clinical outcome data of the 11q23-rearranged subgroups are scarce because most 11q23 series are too small for meaningful analysis of subgroups, although some studies suggest that patients with t(9;11)(p22;q23) have a more favorable prognosis. We retrospectively collected outcome data of 756 children with 11q23- or MLL-rearranged AML from 11 collaborative groups to identify differences in outcome based on translocation partners. All karyotypes were centrally reviewed before assigning patients to subgroups. The event-free survival of 11q23/MLL-rearranged pediatric AML at 5 years from diagnosis was 44% (+/- 5%), with large differences across subgroups (11% +/- 5% to 92% +/- 5%). Multivariate analysis identified the following subgroups as independent prognostic predictors: t(1;11)(q21;q23) (hazard ratio [HR] = 0.1, P = .004); t(6;11)(q27;q23) (HR = 2.2, P < .001); t(10;11)(p12;q23) (HR = 1.5, P = .005); and t(10;11)(p11.2;q23) (HR = 2.5, P = .005). We could not confirm the favorable prognosis of the t(9;11)(p22;q23) subgroup. We identified large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independently predict clinical outcome. Screening for these translocation partners is needed for accurate treatment stratification at diagnosis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
700 | 1 | a Raimondi, Susana C4 aut |
700 | 1 | a Harbott, Jochen4 aut |
700 | 1 | a Zimmermann, Martin4 aut |
700 | 1 | a Alonzo, Todd A4 aut |
700 | 1 | a Auvrignon, Anne4 aut |
700 | 1 | a Beverloo, H Berna4 aut |
700 | 1 | a Chang, Myron4 aut |
700 | 1 | a Creutzig, Ursula4 aut |
700 | 1 | a Dworzak, Michael N4 aut |
700 | 1 | a Forestier, Eriku Umeå universitet,Pediatrik4 aut0 (Swepub:umu)erfo0007 |
700 | 1 | a Gibson, Brenda4 aut |
700 | 1 | a Hasle, Henrik4 aut |
700 | 1 | a Harrison, Christine J4 aut |
700 | 1 | a Heerema, Nyla A4 aut |
700 | 1 | a Kaspers, Gertjan J L4 aut |
700 | 1 | a Leszl, Anna4 aut |
700 | 1 | a Litvinko, Nathalia4 aut |
700 | 1 | a Nigro, Luca Lo4 aut |
700 | 1 | a Morimoto, Akira4 aut |
700 | 1 | a Perot, Christine4 aut |
700 | 1 | a Pieters, Rob4 aut |
700 | 1 | a Reinhardt, Dirk4 aut |
700 | 1 | a Rubnitz, Jeffrey E4 aut |
700 | 1 | a Smith, Franklin O4 aut |
700 | 1 | a Stary, Jan4 aut |
700 | 1 | a Stasevich, Irina4 aut |
700 | 1 | a Strehl, Sabine4 aut |
700 | 1 | a Taga, Takashi4 aut |
700 | 1 | a Tomizawa, Daisuke4 aut |
700 | 1 | a Webb, David4 aut |
700 | 1 | a Zemanova, Zuzana4 aut |
700 | 1 | a Zwaan, C Michel4 aut |
700 | 1 | a van den Heuvel-Eibrink, Marry M4 aut |
710 | 2 | a Umeå universitetb Pediatrik4 org |
773 | 0 | t Bloodd : American Society of Hematologyg 114:12, s. 2489-2496q 114:12<2489-2496x 0006-4971x 1528-0020 |
856 | 4 | u https://europepmc.org/articles/pmc2927031 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42549 |
856 | 4 8 | u https://doi.org/10.1182/blood-2009-04-215152 |
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