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Booster vaccination...
Booster vaccination with recombinant hepatitis B vaccine four years after priming with one single dose
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- Wiström, Johan, 1949- (författare)
- Umeå universitet,Infektionssjukdomar
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- Ahlm, Clas, 1956- (författare)
- Umeå universitet,Infektionssjukdomar,Clas Ahlm
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- Lundberg, Sonia (författare)
- Umeå universitet,Infektionssjukdomar
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- Settergren, Bo (författare)
- tidigare Infektion UmU
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- Tärnvik, Arne, 1940- (författare)
- Umeå universitet,Infektionssjukdomar
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Vaccine. - 0264-410X .- 1873-2518. ; 17:17, s. 2162-2165
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We here studied the antibody response to a booster dose four years after the administration of one single dose of recombinant HB vaccine. Before receiving the booster dose, levels of protective antibodies (anti-HBs) were generally low and 24/41 (59%) individuals lacked detectable antibodies (< 1 IU/L). Within 14 d of booster vaccination, 36/38 (95%) vaccinees showed levels of antibodies > 100 IU/L. Notably, these levels were at least as high as those of a reference group 12 months after initiation of vaccination according to the standard three-dose vaccination at intervals of 0, 1 and 6 months. In conclusion, one single dose of HB vaccine seemed to confer on young healthy individuals a well preserved B cell memory, disclosed as a rapid and strong antibody response to a second dose four years later.
Nyckelord
- Hepatitis B; Vaccination; Immunity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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