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The solution NMR st...
The solution NMR structure of a blue-green algae hepatotoxin, microcystin-RR--a comparison with the structure of microcystin-LR.
- Artikel/kapitelEngelska1998
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LIBRIS-ID:oai:DiVA.org:umu-42943
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42943URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The microcystin-RR structures are compared with the structures of microcystin-LR in solution as well as in the crystal structure of the complex with protein phosphatase. The gross structures of the two peptides are similar, but with a more accentuated and compact saddle structure for microcystin-RR. The structural differences affect the hydrogen-bond pattern in the peptides and the location of the side chain of N-methyldehydroalanine, both of which are important for the ability of the peptide to form a tight complex with protein phosphatase. These structural differences may contribute to the observed differences in toxicity of microcystin-RR and microcystin-LR.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Edlund, U
(författare)
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Larsson, Göran
(författare)
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Sethson, I
(författare)
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Ingår i:European Journal of Biochemistry258:2, s. 301-120014-29561432-1033
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