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The solution NMR st...
The solution NMR structure of a blue-green algae hepatotoxin, microcystin-RR--a comparison with the structure of microcystin-LR.
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Trogen, G B (författare)
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Edlund, U (författare)
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Larsson, Göran (författare)
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visa fler...
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Sethson, I (författare)
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visa färre...
- 1998
- 1998
- Engelska.
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Ingår i: European Journal of Biochemistry. - 0014-2956 .- 1432-1033. ; 258:2, s. 301-12
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The microcystin-RR structures are compared with the structures of microcystin-LR in solution as well as in the crystal structure of the complex with protein phosphatase. The gross structures of the two peptides are similar, but with a more accentuated and compact saddle structure for microcystin-RR. The structural differences affect the hydrogen-bond pattern in the peptides and the location of the side chain of N-methyldehydroalanine, both of which are important for the ability of the peptide to form a tight complex with protein phosphatase. These structural differences may contribute to the observed differences in toxicity of microcystin-RR and microcystin-LR.
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