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Plasma phospholipid...
Plasma phospholipid fatty acid content is related to disease activity in ankylosing spondylitis
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- Sundström, Björn, 1968- (författare)
- Umeå universitet,Reumatologi,Division of Rheumatology, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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- Johansson, Gunnar (författare)
- Högskolan i Halmstad,Centrum för forskning om välfärd, hälsa och idrott (CVHI)
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- Kokkonen, Heidi (författare)
- Umeå universitet,Reumatologi,Division of Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden
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- Cederholm, Tommy (författare)
- Uppsala universitet,Karolinska Institutet,Klinisk nutrition och metabolism
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- Wållberg-Jonsson, Solveig (författare)
- Umeå universitet,Reumatologi,Division of Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2011-12-15
- 2012
- Engelska.
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Ingår i: Journal of Rheumatology. - Toronto : Journal of Rheumatology Pub. Co.. - 0315-162X .- 1499-2752. ; 39:2, s. 327-333
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objectives: To investigate the fatty acid composition in the diet, plasma phospholipids, and adipose tissue among a cohort of patients with ankylosing spondylitis (AS), and to determine their correlation to disease activity and blood lipids in a cross-sectionally designed study. Methods: Diet was assessed using a food frequency questionnaire on 66 patients with AS. The polyunsaturated fatty acids (PUFAs) in plasma phospholipids and gluteal adipose tissue were measured using gas chromatography. Disease status was quantified using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein and pro-inflammatory cytokines. Results: Diet did not correlate to disease activity assessed by the BASDAI, but there were negative correlation between the dietary intake of long-chained omega-3 fatty acids and ESR (rs=-0.27, p<0.05). The plasma phospholipid content of arachidonic acid (AA) correlated significantly with the BASDAI score (rs=0.39, p<0.01). There were correlations between the intake of long-chained omega-3 fatty acids and high-density lipoproteins as well as to serum triglycerides (rs=0.26 and rs=-0.25; respectively, p<0.05). Conclusion: There was a positive correlation between levels of AA in plasma phospholipids and disease activity assessed by BASDAI in patients with AS. A western diet does not appear to influence this correlation, but seems to affect blood lipids involved in atherogenic processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- ankylosing spondylitis
- disease activity
- fatty acids
- diet
- reumatologi
- rheumatology
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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