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Microbiota of sever...
Microbiota of severe early childhood caries before and after therapy
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Tanner, ACR (författare)
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Kent, RL Jr (författare)
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- Holgersson, Pernilla Lif (författare)
- Umeå universitet,Kariologi
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Hughes, CV (författare)
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Loo, CY (författare)
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Kanasi, E (författare)
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Chalmers, NI (författare)
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- Johansson, Ingegerd (författare)
- Umeå universitet,Kariologi
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(creator_code:org_t)
- 2011-08-25
- 2011
- Engelska.
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Ingår i: Journal of Dental Research. - Washington, D.C. : American dental association. - 0022-0345 .- 1544-0591. ; 90:11, s. 1298-1305
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Severe early childhood caries (ECC) is difficult to treat successfully. This study aimed to characterize the microbiota of severe ECC and evaluate whether baseline or follow-up microbiotas are associated with new lesions post-treatment. Plaque samples from 2- to 6-year-old children were analyzed by a 16S rRNA-based microarray and by PCR for selected taxa. Severe-ECC children were monitored for 12 months post-therapy. By microarray, species associated with severe-ECC (n = 53) compared with caries-free (n = 32) children included Slackia exigua (p = 0.002), Streptococcus parasanguinis (p = 0.013), and Prevotella species (p < 0.02). By PCR, severe-ECC-associated taxa included Bifidobacteriaceae (p < 0.001), Scardovia wiggsiae (p = 0.003), Streptococcus mutans with bifidobacteria (p < 0.001), and S. mutans with S. wiggsiae (p = 0.001). In follow-up, children without new lesions (n = 36) showed lower detection of taxa including S. mutans, changes not observed in children with follow-up lesions (n = 17). Partial least-squares modeling separated the children into caries-free and two severe-ECC groups with either a stronger bacterial or a stronger dietary component. We conclude that several species, including S. wiggsiae and S. exigua, are associated with the ecology of advanced caries, that successful treatment is accompanied by a change in the microbiota, and that severe ECC is diverse, with influences from selected bacteria or from diet.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- pediatric dentistry
- clinical outcomes
- microbial ecology
- Streptococcus mutans
- Scardovia wiggsiae
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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