Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:DiVA.org:umu-53190" > Chloroquine for inf...

1 av 1
Föregående post
Nästa post
Till träfflistan

Paton, Nicholas I (författare)

Chloroquine for influenza prevention : a randomised, double-blind, placebo controlled trial

Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

Elsevier,2011
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-53190
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53190URI
https://doi.org/10.1016/S1473-3099(11)70065-2DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

BACKGROUND: Chloroquine has in-vitro activity against influenza and could be an ideal candidate for worldwide prevention of influenza in the period between onset of a pandemic with a virulent influenza strain and the development and widespread dissemination of an effective vaccine. We aimed to assess the efficacy of such an intervention. METHODS: In this randomised, double-blind, placebo-controlled trial done at a single centre in Singapore, we randomly assigned (1:1) healthy adults to receive chloroquine phosphate (500 mg/day for 1 week, then once a week to complete 12 weeks) or matching placebo by use of a computer-generated randomisation list. Participants filled an online symptom diary every week, supplemented by daily diaries and self-administered nasal swabs when unwell. Haemagglutination-inhibition assays for influenza A (H1N1, H3N2) and B were done on blood samples taken at baseline and after 12 weeks. The primary outcome was laboratory-confirmed clinical influenza defined by specific symptoms accompanied by influenza RNA on nasal swabs or a four-fold increase in haemagglutination-inhibition titres over the 12-week study period. Analysis was by intention to treat. This trial was registered with ClinicalTrials.gov, number NCT01078779. FINDINGS: From November, 2009, to February, 2010, we recruited 1516 eligible participants. 1496 (96%) returned at week 12 and were included in the efficacy analysis. Adherence to study intervention was 97%, and 94% of the scheduled weekly diaries were completed. Eight (1%) of 738 participants had laboratory-confirmed clinical influenza in the placebo group and 12 (2%) of 724 in the chloroquine group (relative risk 1·53, 95% CI 0·63-3·72; p=0·376). 29 (4%) of 738 had laboratory-confirmed influenza infection (symptomatic or asymptomatic) in the placebo group and 38 (5%) of 724 in the chloroquine group (1·34, 0·83-2·14; p=0·261). 249 (33%) of 759 participants reported adverse events (mostly mild) in the placebo group and 341 (45%) of 757 in chloroquine group (p<0·0001). Headache, dizziness, nausea, diarrhoea, and blurred vision were more common in the chloroquine group, but rarely resulted in treatment discontinuation. One serious adverse event (hepatitis) was possibly related to chloroquine. INTERPRETATION: Although generally well tolerated by a healthy community population, chloroquine does not prevent infection with influenza. Alternative drugs are needed for large-scale prevention of influenza. FUNDING: National Medical Research Council, Singapore.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lee, Lawrence (författare)
Xu, Ying (författare)
Ooi, Eng Eong (författare)
Cheung, Yin Bun (författare)
Archuleta, Sophia (författare)
Wong, Gerard (författare)
Wilder-Smith, AnneliesYong Loo Lin School of Medicine, National University of Singapore, Singapore(Swepub:umu)anwi0099 (författare)
Yong Loo Lin School of Medicine, National University of Singapore, Singapore (creator_code:org_t)

Sammanhörande titlar

Ingår i:The Lancet - Infectious diseases: Elsevier11:9, s. 677-6831473-30991474-4457

Internetlänk

Hitta via bibliotek

The Lancet - Infectious diseases (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Paton, Nicholas ...; Lee, Lawrence; Xu, Ying; Ooi, Eng Eong; Cheung, Yin Bun; Archuleta, Sophi ...; visa fler...; Wong, Gerard; Wilder-Smith, An ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Artiklar i publikationen: The Lancet - Inf ...

Av lärosätet: Umeå universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se