Sökning: onr:"swepub:oai:DiVA.org:umu-53502" > Total and high-mole...
Fältnamn | Indikatorer | Metadata |
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000 | 04961naa a2200769 4500 | |
001 | oai:DiVA.org:umu-53502 | |
003 | SwePub | |
008 | 120329s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-535022 URI |
024 | 7 | a https://doi.org/10.1093/carcin/bgs1332 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aleksandrova, Krasimira4 aut |
245 | 1 0 | a Total and high-molecular-weight adiponectin and risk of colorectal cancer :b the European prospective investigation into cancer and nutrition study |
264 | c 2012-03-19 | |
264 | 1 | b Oxford University Press (OUP),c 2012 |
338 | a print2 rdacarrier | |
520 | a Adiponectin - an adipose-tissue-derived protein may provide a molecular link between obesity and colorectal cancer (CRC), but evidence from large prospective studies is limited. In particular, no epidemiological study explored high-molecular-weight (HMW) and non-HMW adiponectin fractions in relation to CRC risk, despite they were hypothesised to have differential biological activities, i.e. regulating insulin sensitivity (HMW-adiponectin) versus inflammatory response (non-HMW-adiponectin). In a prospective nested case-control study we investigated whether pre-diagnostic serum concentrations of total, HMW and non-HMW-adiponectin are associated with risk of CRC, independent of obesity and other known CRC risk factors. A total of 1206 incident cases (755 colon, 451 rectal) were matched to 1206 controls using incidence density sampling. In conditional logistic regression, adjusted for dietary and lifestyle factors, total adiponectin and non-HMW-adiponectin concentrations were inversely associated with risk of CRC [relative risk (RR) comparing highest versus lowest quintile = 0.71, 95% confidence interval (CI) = 0.53-0.95, P (trend)=0.03 for total adiponectin and 0.45, 95%CI=0.34-0.61, P (trend)<0.0001 for non-HMW-adiponectin]. HMW-adiponectin concentrations were not associated with CRC risk (RR=0.91, 95%CI=0.68-1.22, P (trend)=0.55). Non-HMW-adiponectin was associated with CRC risk even after adjustment for body mass index and waist circumference (RR=0.39, 95%CI=0.26-0.60, P (trend)<0.0001); whereas the association with total adiponectin was no longer significant (RR=0.81, 95%CI=0.60-1.09, P (trend)=0.23). When stratified by cancer site, non-HMW-adiponectin was inversely associated with both colon and rectal cancer. These findings suggest an important role of the relative proportion of non-HMW-adiponectin in CRC pathogenesis. Future studies are warranted to confirm these results and to elucidate the underlying mechanisms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Bueno-de-Mesquita, H Bas4 aut |
700 | 1 | a Jansen, Eugene4 aut |
700 | 1 | a van Duijnhoven, Fränzel JB4 aut |
700 | 1 | a Fedirko, Veronika4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Romaguera, Dora4 aut |
700 | 1 | a Westphal, Sabine4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Boutron-Ruault, Marie Christine4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Lukanova, Annekatrin4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Agnoli, Claudia4 aut |
700 | 1 | a Mattiello, Amalia4 aut |
700 | 1 | a Saieva, Calogero4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Peeters, Petra H4 aut |
700 | 1 | a Argüelles, Marcial4 aut |
700 | 1 | a Bonet, Catalina4 aut |
700 | 1 | a Sánchez, María-José4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Huerta, Jose-María4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001 |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nick4 aut |
700 | 1 | a Allen, Naomi E4 aut |
700 | 1 | a Crowe, Francesca L4 aut |
700 | 1 | a Pischon, Tobias4 aut |
710 | 2 | a Umeå universitetb Patologi4 org |
773 | 0 | t Carcinogenesisd : Oxford University Press (OUP)g 33:6, s. 1211-1218q 33:6<1211-1218x 0143-3334x 1460-2180 |
856 | 4 | u https://academic.oup.com/carcin/article-pdf/33/6/1211/17290932/bgs133.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53502 |
856 | 4 8 | u https://doi.org/10.1093/carcin/bgs133 |
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