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Pharmaceutical salt...
Pharmaceutical salts of fluoroquinolone antibacterial drugs with acesulfame sweetener
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- Basavoju, Srinivas (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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- Boström, Dan (författare)
- Umeå universitet,Energiteknik och termisk processkemi,Energy Technology and Thermal Process Chemistry, Umeå University
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- Velaga, Sitaram (författare)
- Luleå tekniska universitet,Medicinsk vetenskap
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(creator_code:org_t)
- 2012-07-30
- 2012
- Engelska.
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Ingår i: Molecular Crystals and Liquid Crystals. - : Informa UK Limited. - 1542-1406 .- 1563-5287. ; 562:1, s. 254-264
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Novel organic salts of norfloxacin and ciprofloxacin with artificial sweeteners such as saccharin and acesulfame were prepared. The two salts 1 and 2 were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Finally, the crystal structures were solved by single crystal X-ray diffraction data and the structures were analyzed in terms of supramolecular synthons. In norfloxacin acesulfamate 1, two norfloxacin cations and two acesulfame anions form an eight membered cyclic tetramer supramolecular synthon. The salt, ciprofloxacin acesulfamate 2, has a similar structure as salt 1. This study contributes the importance of crystal engineering and supramolecular chemistry to the pharmaceutical applications in terms of interactions and structural correlations in the design of new solid phases. Supplemental materials are available for this article. Go to the publisher's online edition of Molecular Crystals and Liquid Crystals to view the free supplemental file.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
Nyckelord
- Acesulfame
- ciprofloxacin
- ciprofloxacin acesulfamate
- norfloxacin
- norfloxacin acesulfamate
- supramolecular cyclic tetramer synthon
- Health Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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