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Sökning: onr:"swepub:oai:DiVA.org:umu-61772" > Leptin and soluble ...

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FältnamnIndikatorerMetadata
00004753naa a2200769 4500
001oai:DiVA.org:umu-61772
003SwePub
008121126s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-617722 URI
0247 a https://doi.org/10.1158/0008-5472.CAN-12-04652 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aleksandrova, Krasimira4 aut
2451 0a Leptin and soluble leptin receptor in risk of colorectal cancer in the European prospective investigation into Cancer and nutrition cohort
264 1a Philadelphia, USA :b American Association for Cancer Research,c 2012
338 a print2 rdacarrier
520 a Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40-0.76; P-trend = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28-0.63, P-trend = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48-1.44, P-trend = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56-1.29, P-trend = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. Cancer Res; 72(20); 5328-37. (C) 2012 AACR.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Boeing, Heiner4 aut
7001 a Jenab, Mazda4 aut
7001 a Bueno-de-Mesquita, H. Bas4 aut
7001 a Jansen, Eugene4 aut
7001 a van Duijnhoven, Franzel J. B.4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Fedirko, Veronika4 aut
7001 a Romieu, Isabelle4 aut
7001 a Riboli, Elio4 aut
7001 a Gunter, Marc J.4 aut
7001 a Westphal, Sabine4 aut
7001 a Overvad, Kim4 aut
7001 a Tjonneland, Anne4 aut
7001 a Halkjaer, Jytte4 aut
7001 a Racine, Antoine4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Clavel-Chapelon, Francoise4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Lukanova, Annekatrin4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Mattiello, Amalia4 aut
7001 a Pala, Valeria4 aut
7001 a Palli, Domenico4 aut
7001 a Tumino, Rosario4 aut
7001 a Vineis, Paolo4 aut
7001 a Buckland, Genevieve4 aut
7001 a Sanchez, Maria-Jose4 aut
7001 a Amiano, Pilar4 aut
7001 a Maria Huerta, Jose4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Menendez, Virginia4 aut
7001 a Peeters, Petra H.4 aut
7001 a Söderberg, Stefanu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)stso0001
7001 a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
7001 a Allen, Naomi E.4 aut
7001 a Crowe, Francesca L.4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nickolas4 aut
7001 a Pischon, Tobias4 aut
7102 a Umeå universitetb Kardiologi4 org
7730 t Cancer Researchd Philadelphia, USA : American Association for Cancer Researchg 72:20, s. 5328-5337q 72:20<5328-5337x 0008-5472x 1538-7445
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-61772
8564 8u https://doi.org/10.1158/0008-5472.CAN-12-0465

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