Sökning: onr:"swepub:oai:DiVA.org:umu-62168" > Defining the genomi...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04233naa a2200613 4500 | |
001 | oai:DiVA.org:umu-62168 | |
003 | SwePub | |
008 | 121210s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-621682 URI |
024 | 7 | a https://doi.org/10.1186/1755-8794-5-462 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Peri, Suraj4 aut |
245 | 1 0 | a Defining the genomic signature of the parous breast |
264 | c 2012-10-11 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
338 | a print2 rdacarrier | |
520 | a Background: It is accepted that a woman's lifetime risk of developing breast cancer after menopause is reduced by early full term pregnancy and multiparity. This phenomenon is thought to be associated with the development and differentiation of the breast during pregnancy.Methods: In order to understand the underlying molecular mechanisms of pregnancy induced breast cancer protection, we profiled and compared the transcriptomes of normal breast tissue biopsies from 71 parous (P) and 42 nulliparous (NP) healthy postmenopausal women using Affymetrix Human Genome U133 Plus 2.0 arrays. To validate the results, we performed real time PCR and immunohistochemistry.Results: We identified 305 differentially expressed probesets (208 distinct genes). Of these, 267 probesets were up- and 38 down-regulated in parous breast samples; bioinformatics analysis using gene ontology enrichment revealed that up-regulated genes in the parous breast represented biological processes involving differentiation and development, anchoring of epithelial cells to the basement membrane, hemidesmosome and cell-substrate junction assembly, mRNA and RNA metabolic processes and RNA splicing machinery. The down-regulated genes represented biological processes that comprised cell proliferation, regulation of IGF-like growth factor receptor signaling, somatic stem cell maintenance, muscle cell differentiation and apoptosis.Conclusions: This study suggests that the differentiation of the breast imprints a genomic signature that is centered in the mRNA processing reactome. These findings indicate that pregnancy may induce a safeguard mechanism at post-transcriptional level that maintains the fidelity of the transcriptional process. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Gene expression profiling | |
653 | a Pregnancy | |
653 | a Breast morphology | |
653 | a Breast differentiation | |
653 | a Parous and nulliparous breast transcriptome | |
653 | a Breast cancer risk | |
653 | a Normal breast transcriptome | |
653 | a Bioinformatics | |
700 | 1 | a de Cicco, Ricardo Lopez4 aut |
700 | 1 | a Santucci-Pereira, Julia4 aut |
700 | 1 | a Slifker, Michael4 aut |
700 | 1 | a Ross, Eric A4 aut |
700 | 1 | a Russo, Irma H4 aut |
700 | 1 | a Russo, Patricia A4 aut |
700 | 1 | a Arslan, Alan A4 aut |
700 | 1 | a Belitskaya-Levy, Ilana4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a Bordas, Palu Umeå universitet,Onkologi4 aut0 (Swepub:umu)palbos99 |
700 | 1 | a Lenner, Peru Umeå universitet,Onkologi4 aut0 (Swepub:umu)pele0005 |
700 | 1 | a Åhman, Janet4 aut |
700 | 1 | a Afanasyeva, Yelena4 aut |
700 | 1 | a Johansson, Robertu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)rojo0001 |
700 | 1 | a Sheriff, Fathima4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Toniolo, Paolo4 aut |
700 | 1 | a Russo, Jose4 aut |
710 | 2 | a Umeå universitetb Onkologi4 org |
773 | 0 | t BMC Medical Genomicsd : Springer Science and Business Media LLCg 5, s. 46-q 5<46-x 1755-8794 |
856 | 4 | u https://bmcmedgenomics.biomedcentral.com/track/pdf/10.1186/1755-8794-5-46 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-62168 |
856 | 4 8 | u https://doi.org/10.1186/1755-8794-5-46 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy