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Iron supplements re...
Iron supplements reduce erythrocyte copper-zinc superoxide dismutase activity in term, breastfed infants.
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- Domellöf, Magnus (författare)
- Umeå universitet,Pediatrik
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Dewey, Kathryn G (författare)
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Cohen, Roberta J (författare)
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Lönnerdal, Bo (författare)
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- Hernell, Olle (författare)
- Umeå universitet,Pediatrik
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Acta Paediatr. - 0803-5253. ; 94:11, s. 1578-82
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- AIM: To investigate whether iron supplements compromise copper status in infants. METHODS: 214 healthy, term, breastfed Swedish and Honduran infants were randomized to (1) iron supplements (1 mg/kg/d) from 4-9 mo of age, (2) iron supplements from 6-9 mo, or (3) placebo. Blood samples were obtained at 4, 6, and 9 mo and analyzed for plasma copper (p-Cu) and, at 9 mo, for copper/zinc-dependent superoxide dismutase (CuZn-SOD) activity. RESULTS: P-Cu increased with infant age. At 9 mo, Honduran infants had significantly higher p-Cu (1.40+/-0.29 vs 1.09+/-0.22 mg/l, p<0.001) and CuZn-SOD activity (1.09+/-0.29 vs 0.93+/-0.21 U/mg Hb, p<0.001) than Swedish infants. Infants receiving iron supplements from 4-9 mo had significantly lower CuZn-SOD at 9 mo of age (0.95+/-0.27 vs 1.08+/-0.24 U/mg Hb, p=0.023) than those receiving placebo.CONCLUSION: There is a physiologic increase in p-Cu during the first 9 mo of life. Differences in copper status between Swedish and Honduran infants may be due to genetic or nutritional differences. Iron supplementation decreases CuZn-SOD activity, probably due to a negative effect on copper status. Possible clinical implications remain to be elucidated.
Nyckelord
- Adult
- Age Factors
- Breast Feeding
- Copper/*blood
- Cross-Cultural Comparison
- Dietary Supplements/*adverse effects
- Female
- Ferrous Compounds/*adverse effects
- Honduras
- Humans
- Infant
- Linear Models
- Male
- Multivariate Analysis
- Superoxide Dismutase/*blood/drug effects
- Sweden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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