Sökning: onr:"swepub:oai:DiVA.org:umu-71395" >
Effect of HIV infec...
Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa : secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA)
-
- Zaba, Basia (författare)
- London School of Hygiene & Tropical Medicine, London, UK
-
- Calvert, Clara (författare)
- London School of Hygiene & Tropical Medicine, London, UK
-
- Marston, Milly (författare)
- London School of Hygiene & Tropical Medicine, London, UK
-
visa fler...
-
- Isingo, Raphael (författare)
- National Institute for Medical Research, Tanzania, Mwanza, Tanzania
-
- Nakiyingi-Miiro, Jessica (författare)
- MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
-
- Lutalo, Tom (författare)
- Rakai Health Sciences Program, Rakai, Uganda
-
- Crampin, Amelia (författare)
- Karonga Prevention Study, Karonga, Malawi and London School of Hygiene & Tropical Medicine, London, UK
-
- Robertson, Laura (författare)
- INDEPTH Network, Accra, Ghana
-
- Herbst, Kobus (författare)
- Africa Centre for Health and Population Studies, University of KwaZulu-Natal, KwaZulu-Natal, South Africa
-
- Newell, Marie-Louise (författare)
- Africa Centre for Health and Population Studies, University of KwaZulu-Natal, KwaZulu-Natal, South Africa
-
- Todd, Jim (författare)
- London School of Hygiene & Tropical Medicine, London, UK
-
- Byass, Peter (författare)
- Umeå universitet,Epidemiologi och global hälsa,INDEPTH Network, Accra, Ghana
-
- Boerma, Ties (författare)
- WHO, Geneva, Switzerland
-
- Ronsmans, Carine (författare)
- London School of Hygiene & Tropical Medicine, London, UK
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2013
- 2013
- Engelska.
-
Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 381:9879, s. 1763-1771
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Model-based estimates of the global proportions of maternal deaths that are in HIV-infected women range from 7% to 21%, and the effects of HIV on the risk of maternal death is highly uncertain. We used longitudinal data from the Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA) network to estimate the excess mortality associated with HIV during pregnancy and the post-partum period in sub-Saharan Africa.METHODS: The ALPHA network pooled data gathered between June, 1989 and April, 2012 in six community-based studies in eastern and southern Africa with HIV serological surveillance and verbal-autopsy reporting. Deaths occurring during pregnancy and up to 42 days post partum were defined as pregnancy related. Pregnant or post-partum person-years were calculated for HIV-infected and HIV-uninfected women, and HIV-infected to HIV-uninfected mortality rate ratios and HIV-attributable rates were compared between pregnant or post-partum women and women who were not pregnant or post partum.FINDINGS: 138,074 women aged 15-49 years contributed 636,213 person-years of observation. 49,568 women had 86,963 pregnancies. 6760 of these women died, 235 of them during pregnancy or the post-partum period. Mean prevalence of HIV infection across all person-years in the pooled data was 17.2% (95% CI 17.0-17.3), but 60 of 118 (50.8%) of the women of known HIV status who died during pregnancy or post partum were HIV infected. The mortality rate ratio of HIV-infected to HIV-uninfected women was 20.5 (18.9-22.4) in women who were not pregnant or post partum and 8.2 (5.7-11.8) in pregnant or post-partum women. Excess mortality attributable to HIV was 51.8 (47.8-53.8) per 1000 person-years in women who were not pregnant or post partum and 11.8 (8.4-15.3) per 1000 person-years in pregnant or post-partum women.INTERPRETATION: HIV-infected pregnant or post-partum women had around eight times higher mortality than did their HIV-uninfected counterparts. On the basis of this estimate, we predict that roughly 24% of deaths in pregnant or post-partum women are attributable to HIV in sub-Saharan Africa, suggesting that safe motherhood programmes should pay special attention to the needs of HIV-infected pregnant or post-partum women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Zaba, Basia
-
Calvert, Clara
-
Marston, Milly
-
Isingo, Raphael
-
Nakiyingi-Miiro, ...
-
Lutalo, Tom
-
visa fler...
-
Crampin, Amelia
-
Robertson, Laura
-
Herbst, Kobus
-
Newell, Marie-Lo ...
-
Todd, Jim
-
Byass, Peter
-
Boerma, Ties
-
Ronsmans, Carine
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
The Lancet
- Av lärosätet
-
Umeå universitet