Viral load and humoral immune response in association with disease severity in Puumala hantavirus-infected patients-implications for treatment

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Fältnamn	Indikatorer	Metadata
000		04424naa a2200577 4500
001		oai:DiVA.org:umu-74938
003		SwePub
008		130702s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:128425009
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-749382 URI
024	7	a https://doi.org/10.1111/1469-0691.122592 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1284250092 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Pettersson, Lisau Umeå universitet,Virologi4 aut0 (Swepub:umu)liapen96
245	1 0	a Viral load and humoral immune response in association with disease severity in Puumala hantavirus-infected patients-implications for treatment
264	1	b Wiley-Blackwell,c 2014
338		a electronic2 rdacarrier
520		a Hantaviruses are the causative agents of haemorrhagic fever with renal syndrome (HFRS) in Eurasia and of hantavirus cardiopulmonary syndrome (HCPS) in the Americas. The case fatality rate varies between different hantaviruses and can be up to 40%. At present, there is no specific treatment available. The hantavirus pathogenesis is not well understood, but most likely, both virus-mediated and host-mediated mechanisms are involved. The aim of the present study was to investigate the association among Puumala hantavirus (PUUV) viral RNA load, humoral immune response and disease severity in patients with HFRS. We performed a study of 105 PUUV-infected patients that were followed during the acute phase of disease and for up to 1-3 months later. Fifteen of the 105 patients (14%) were classified as having moderate/severe disease. A low PUUV-specific IgG response (p <0.05) and also a higher white blood cell count (p <0.001) were significantly associated with more severe disease. The PUUV RNA was detected in a majority of patient plasma samples up to 9 days after disease onset; however, PUUV RNA load or longevity of viraemia were not significantly associated with disease severity. We conclude that a low specific IgG response was associated with disease severity in patients with HFRS, whereas PUUV RNA load did not seem to affect the severity of HFRS. Our results raise the possibility of passive immunotherapy as a useful treatment for hantavirus-infected patients.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653		a age
653		a disease severity
653		a hantavirus
653		a haemorrhagic fever with renal syndrome
653		a humoral immune response
653		a immunoglobulins
653		a neutrophil
653		a Puumala virus
653		a viral load
653		a white blood cell count
653		a mikrobiologi
653		a Microbiology
700	1	a Thunberg, Therese,d 1977-u Umeå universitet,Infektionssjukdomar4 aut0 (Swepub:umu)thelin96
700	1	a Rocklöv, Joacimu Umeå universitet,Epidemiologi och global hälsa,Arcum4 aut0 (Swepub:umu)joro0003
700	1	a Klingström, Jonasu Karolinska Institutet4 aut
700	1	a Evander, Magnusu Umeå universitet,Virologi,Arcum4 aut0 (Swepub:umu)maev0001
700	1	a Ahlm, Clasu Umeå universitet,Infektionssjukdomar,Arcum4 aut0 (Swepub:umu)clah0001
710	2	a Umeå universitetb Virologi4 org
773	0	t Clinical Microbiology and Infectiond : Wiley-Blackwellg 20:3, s. 235-241q 20:3<235-241x 1198-743Xx 1469-0691
856	4	u https://doi.org/10.1111/1469-0691.12259y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:635009/FULLTEXT04.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.clinicalmicrobiologyandinfection.com/article/S1198743X14608648/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-74938
856	4 8	u https://doi.org/10.1111/1469-0691.12259
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:128425009

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Av författaren/redakt...: Pettersson, Lisa; Thunberg, Theres ...; Rocklöv, Joacim; Klingström, Jona ...; Evander, Magnus; Ahlm, Clas

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

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