Sökning: onr:"swepub:oai:DiVA.org:umu-76659" > Polymorphisms of H....
Fältnamn | Indikatorer | Metadata |
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000 | 05092naa a2200925 4500 | |
001 | oai:DiVA.org:umu-76659 | |
003 | SwePub | |
008 | 130709s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-766592 URI |
024 | 7 | a https://doi.org/10.1002/ijc.283572 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Companioni, Osmel4 aut |
245 | 1 0 | a Polymorphisms of H. pylori signaling pathway genes and gastric cancer risk in the European EPIC-eurgast cohort |
264 | c 2013-08-13 | |
264 | 1 | b Wiley-Blackwell,c 2014 |
338 | a print2 rdacarrier | |
500 | a Article first published online: 13 Aug 2013 | |
520 | a Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccaride and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. SNPs in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1284 matched controls from the EPIC cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log-additive model we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p=0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p=0.0003) and CD14 with cardia GC (p=0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a gastric cancer | |
653 | a genetic susceptibility | |
653 | a Helicobacter pylori | |
653 | a NOD2 | |
653 | a CD14 | |
700 | 1 | a Bonet, Catalina4 aut |
700 | 1 | a Muñoz, Xavier4 aut |
700 | 1 | a Weiderpass, Elisabete4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Agnoli, Claudia4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Racine, Antoine4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Murphy, Neil4 aut |
700 | 1 | a Vergnaud, Anne-Claire4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Benetou, Vassiliki4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Johansen, Dorthe4 aut |
700 | 1 | a Lindkvist, Björn4 aut |
700 | 1 | a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer (IARC-WHO), Lyon, France4 aut0 (Swepub:umu)masmas97 |
700 | 1 | a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Sánchez-Cantalejo, Emilio4 aut |
700 | 1 | a Huerta, Jose M4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Quirós, José Ramón4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Mortensen, Lotte Maxild4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Rizzato, Cosmeri4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a de Mesquita, H Bas Bueno4 aut |
700 | 1 | a Siersema, Peter4 aut |
700 | 1 | a Peeters, Petra Hm4 aut |
700 | 1 | a Numans, Mattijs E4 aut |
700 | 1 | a Carneiro, Fatima4 aut |
700 | 1 | a Licaj, Idlir4 aut |
700 | 1 | a Freisling, Heinz4 aut |
700 | 1 | a Sala, Núria4 aut |
700 | 1 | a González, Carlos A4 aut |
710 | 2 | a Umeå universitetb Enheten för biobanksforskning4 org |
773 | 0 | t International Journal of Cancerd : Wiley-Blackwellg 134:1, s. 92-101q 134:1<92-101x 0020-7136x 1097-0215 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28357 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76659 |
856 | 4 8 | u https://doi.org/10.1002/ijc.28357 |
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