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Interleukin-10 prom...
Interleukin-10 promoter polymorphism IL10.G and familial early onset psoriasis
- Artikel/kapitelEngelska2003
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John Wiley & Sons,2003
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LIBRIS-ID:oai:DiVA.org:umu-82437
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82437URI
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https://doi.org/10.1046/j.1365-2133.2003.05411.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: The anti-inflammatory cytokine interleukin (IL)-10 is considered to play a major role in the pathophysiology of psoriasis, which is characterized by an IL-10 deficiency. Systemic administration of IL-10 has been shown to be an effective therapy for psoriasis. The IL-10 promoter region contains a highly polymorphic microsatellite (IL10.G) and in a recent case-control study the IL10.G13 (144 bp) allele was found to be associated with familial early onset psoriasis (type 1 psoriasis) having a susceptible effect.OBJECTIVES: As it is essential in multifactorial diseases to replicate findings before definite conclusions can be drawn, we decided to perform a follow-up study and to follow a genetic approach analysing allele transmission in families with a positive family history of psoriasis.METHODS: We studied 137 nuclear families (trio-design) comprising 456 individuals and genotyped the IL10.G marker. For comparison we also genotyped the microsatellite tn62 as a reference marker of the major psoriasis susceptibility locus on chromosome 6p21 (PSORS1). In the present study allele transmission was evaluated using the family-based association test (FBAT) and GENEHUNTER 2.0 based on the transmission/disequilibrium test.RESULTS: The G13 allele (144 bp) had a frequency of 24%, was present in 88 families and clearly showed an even transmission (FBAT, P = 0.753). In contrast, allele 3 (IL10.G9) (136 bp) had a frequency of 39%, was present in 110 families and was transmitted in 43 trios and remained untransmitted in 67 trios (FBAT, P = 0.026), thus showing preferential nontransmission. For the HLA-linked tn62-marker we obtained a P-value of 0.00027 for allele 4 in the same study group.CONCLUSIONS: In conclusion, we failed to confirm the susceptible effect of the G13 allele, but provide the first data for a protective effect of allele 3 (IL10.G9) for familial psoriasis. Our results suggest that the IL10.G polymorphism is not a major locus, but acts as a minor locus.
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Asadullah, K
(författare)
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Windemuth, C
(författare)
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Rüschendorf, F
(författare)
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Hüffmeier, U
(författare)
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Ständer, M
(författare)
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Schmitt-Egenolf, MarcusUmeå universitet,Dermatologi och venereologi(Swepub:umu)masc0001
(författare)
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Wienker, TF
(författare)
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Reis, A
(författare)
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Traupe, H
(författare)
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Umeå universitetDermatologi och venereologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Dermatology: John Wiley & Sons149:2, s. 381-3850007-09631365-2133
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Hensen, P
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Asadullah, K
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Windemuth, C
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Rüschendorf, F
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Hüffmeier, U
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Ständer, M
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Schmitt-Egenolf, ...
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Wienker, TF
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Reis, A
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Traupe, H
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