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Low-dose prednisolo...
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Engvall, Inga-LillKarolinska Institutet
(författare)
Low-dose prednisolone in early rheumatoid arthritis inhibits collagen type I degradation by matrix metalloproteinases as assessed by serum 1CTP--a possible mechanism for specific inhibition of radiological destruction
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2012-12-28
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Oxford University Press (OUP),2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-82922
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82922URI
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https://doi.org/10.1093/rheumatology/kes369DOI
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https://gup.ub.gu.se/publication/170664URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126459716URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE: To study the effects of low-dose prednisolone on the osteoclast-regulating proteins osteoprotegerin (OPG) and RANK ligand (RANKL) and on markers of bone resorption, 1CTP generated by MMPs and CTX-1 generated by cathepsin K, in patients with early RA in relation to inflammation and joint destruction.METHODS: In 225 patients, who at the start of the first DMARD had been randomized to 7.5 mg prednisolone daily for 2 years, the P-group, or no prednisolone, the NoP-group, OPG and RANKL were analysed at 0-24 months and 1CTP and CTX-1 at 0-12 months. Radiographs of hands and feet were assessed at 0, 1 and 2 years using the modified Sharp-van der Heijde score and radiological progression defined as increase in total Sharp score above 5.8. Data were analysed with a mixed linear model and by the GENMOD procedure.RESULTS: In the P-group, RANKL and the ratio OPG/RANKL were stable between baseline and 24 months, whereas in the NoP-group, RANKL increased and the ratio OPG/RANKL decreased. CTX-1 decreased significantly more in the P-group. 1CTP decreased over time in both groups, but more in the P-group, P < 0.001, a difference also present in the subgroups of patients in remission. The decrease in 1CTP was associated with less radiological progression after 2 years and displayed a significant interaction with treatment. CONCLUSION: Low-dose prednisolone may inhibit progression of joint destruction by interfering with MMP activity, seen as a marked decrease in 1CTP, as well as by impairing osteoclast activation, shown by a stable OPG/RANKL ratio.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Svensson, Björn
(författare)
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Boonen, Annelies
(författare)
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van der Heijde, Désirée
(författare)
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Lerner, Ulf HGothenburg University,Göteborgs universitet,Umeå universitet,Institutionen för odontologi,Centre for Bone and Arthritis Research(Swepub:gu)xlerul
(författare)
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Hafström, IngiäldKarolinska Institutet
(författare)
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Karolinska InstitutetInstitutionen för odontologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Rheumatology: Oxford University Press (OUP)52:4, s. 733-7421462-03241462-0332
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