Sökning: onr:"swepub:oai:DiVA.org:umu-82922" > Low-dose prednisolo...
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000 | 04463naa a2200565 4500 | |
001 | oai:DiVA.org:umu-82922 | |
003 | SwePub | |
008 | 131113s2013 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/170664 | |
009 | oai:prod.swepub.kib.ki.se:126459716 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-829222 URI |
024 | 7 | a https://doi.org/10.1093/rheumatology/kes3692 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/1706642 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1264597162 URI |
040 | a (SwePub)umud (SwePub)gud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Engvall, Inga-Lillu Karolinska Institutet4 aut |
245 | 1 0 | a Low-dose prednisolone in early rheumatoid arthritis inhibits collagen type I degradation by matrix metalloproteinases as assessed by serum 1CTP--a possible mechanism for specific inhibition of radiological destruction |
264 | c 2012-12-28 | |
264 | 1 | b Oxford University Press (OUP),c 2013 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE: To study the effects of low-dose prednisolone on the osteoclast-regulating proteins osteoprotegerin (OPG) and RANK ligand (RANKL) and on markers of bone resorption, 1CTP generated by MMPs and CTX-1 generated by cathepsin K, in patients with early RA in relation to inflammation and joint destruction.METHODS: In 225 patients, who at the start of the first DMARD had been randomized to 7.5 mg prednisolone daily for 2 years, the P-group, or no prednisolone, the NoP-group, OPG and RANKL were analysed at 0-24 months and 1CTP and CTX-1 at 0-12 months. Radiographs of hands and feet were assessed at 0, 1 and 2 years using the modified Sharp-van der Heijde score and radiological progression defined as increase in total Sharp score above 5.8. Data were analysed with a mixed linear model and by the GENMOD procedure.RESULTS: In the P-group, RANKL and the ratio OPG/RANKL were stable between baseline and 24 months, whereas in the NoP-group, RANKL increased and the ratio OPG/RANKL decreased. CTX-1 decreased significantly more in the P-group. 1CTP decreased over time in both groups, but more in the P-group, P < 0.001, a difference also present in the subgroups of patients in remission. The decrease in 1CTP was associated with less radiological progression after 2 years and displayed a significant interaction with treatment. CONCLUSION: Low-dose prednisolone may inhibit progression of joint destruction by interfering with MMP activity, seen as a marked decrease in 1CTP, as well as by impairing osteoclast activation, shown by a stable OPG/RANKL ratio. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a rheumatoid arthritis | |
653 | a prednisolone | |
653 | a joint destruction | |
653 | a OPG | |
653 | a RANKL | |
653 | a 1CTP | |
653 | a CTX-1 | |
700 | 1 | a Svensson, Björn4 aut |
700 | 1 | a Boonen, Annelies4 aut |
700 | 1 | a van der Heijde, Désirée4 aut |
700 | 1 | a Lerner, Ulf Hu Gothenburg University,Göteborgs universitet,Umeå universitet,Institutionen för odontologi,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlerul |
700 | 1 | a Hafström, Ingiäldu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för odontologi4 org |
773 | 0 | t Rheumatologyd : Oxford University Press (OUP)g 52:4, s. 733-742q 52:4<733-742x 1462-0324x 1462-0332 |
856 | 4 | u https://academic.oup.com/rheumatology/article-pdf/52/4/733/5085295/kes369.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82922 |
856 | 4 8 | u https://doi.org/10.1093/rheumatology/kes369 |
856 | 4 8 | u https://gup.ub.gu.se/publication/170664 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126459716 |
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