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Association Between...
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Carlsson, Axel CKarolinska Institutet,Uppsala universitet,Geriatrik,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
(författare)
Association Between Circulating Endostatin, Hypertension Duration, and Hypertensive Target-Organ Damage
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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Lippincott Williams & Wilkins,2013
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-83887
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83887URI
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https://doi.org/10.1161/HYPERTENSIONAHA.113.02250DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-13378URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211651URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127712804URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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De två (2) första författarna delar förstaförfattarskapet.
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Our aim is to study associations between circulating endostatin, hypertension duration, and hypertensive target-organ damage. Long-term hypertension induces cardiovascular and renal remodeling. Circulating endostatin, a biologically active derivate of collagen XVIII, has been suggested to be a relevant marker for extracellular matrix turnover and remodeling in various diseases. However, the role of endostatin in hypertension and hypertensive target-organ damage is unclear. Serum endostatin was measured in 2 independent community-based cohorts: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 51%; n=812; mean age, 75 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=785; mean age, 77.6 years). Retrospective data on blood pressure measurements and antihypertensive medication (PIVUS >5 years, ULSAM >27 years), and cross-sectional data on echocardiographic left ventricular mass, endothelial function (endothelium-dependent vasodilation assessed by the invasive forearm model), and urinary albumin/creatinine ratio were available. In PIVUS, participants with 5 years of history of hypertension portrayed 0.42 SD (95% confidence interval, 0.23-0.61; P<0.001) higher serum endostatin, compared with that of normotensives. This association was replicated in ULSAM, in which participants with 27 years hypertension duration had the highest endostatin (0.57 SD higher; 95% confidence interval, 0.35-0.80; P<0.001). In addition, higher endostatin was associated with higher left ventricular mass, worsened endothelial function, and higher urinary albumin/creatinine ratio (P<0.03 for all) in participants with prevalent hypertension. Circulating endostatin is associated with the duration of hypertension, and vascular, myocardial, and renal indices of hypertensive target-organ damage. Further studies are warranted to assess the prognostic role of endostatin in individuals with hypertension.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ruge, ToralphUppsala universitet,Umeå universitet,Kirurgi,Geriatrik(Swepub:umu)toru0001
(författare)
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Sundström, JohanUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)johasund
(författare)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(författare)
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Larsson, AndersUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)andlarss
(författare)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(författare)
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Ärnlöv, Johan,1970-Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)johaarnl
(författare)
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Uppsala universitetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Hypertension: Lippincott Williams & Wilkins62:6, s. 1146-11510194-911X1524-4563
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