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The influence of ti...
The influence of time sampling scheme on kinetic parameters obtained from compartmental modeling of a dynamic PET study : a Monte Carlo study
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- Häggström, Ida (författare)
- Umeå universitet,Radiofysik
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- Larsson, Anne (författare)
- Umeå universitet,Radiofysik
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- Axelsson, Jan (författare)
- Umeå universitet,Radiofysik
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- Garpebring, Anders (författare)
- Umeå universitet,Radiofysik
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- Johansson, Lennart (författare)
- Umeå universitet,Radiofysik
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- Schmidtlein, C. Ross (författare)
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA
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- Sörensen, Jens (författare)
- Medical Sciences, Nuclear Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Karlsson, Mikael (författare)
- Umeå universitet,Radiofysik
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(creator_code:org_t)
- Anaheim : IEEE conference proceedings, 2012
- 2012
- Engelska.
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Ingår i: IEEE Nuclear Science Symposium Conference Record. - Anaheim : IEEE conference proceedings. - 9781467320306 ; , s. 3101-3107
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Compartmental modeling of dynamic PET data enables quantification of tracer kinetics in vivo, through the obtained model parameters. The dynamic data is sorted into frames during or after the acquisition, with a sampling interval usually ranging from 10 s to 300 s. In this study we wanted to investigate the effect of the chosen sampling interval on kinetic parameters obtained from a 2-tissue model, in terms of bias and standard deviation, using a complete Monte Carlo simulated dynamic F-18-FLT PET study. The results show that the bias and standard deviation in parameter K-1 is small regardless of sampling scheme or noise in the time-activity curves (TACs), and that the bias and standard deviation in k(4) is large for all cases. The bias in V-a is clearly dependent on sampling scheme, increasing for increased sampling interval. In general, a too short sampling interval results in very noisy images and a large bias of the parameter estimate, and a too long sampling interval also increases bias. Noise in the TACs is the largest source of bias.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Nyckelord
- PET
- dynamic PET
- Monte Carlo
- GATE
- compartment model
- time sampling
- sampling interval
- AIF
- FLT
- radiofysik
- radiation physics
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
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