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Serotonergic nerve ...
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Nevalainen, NinaUmeå universitet,Histologi med cellbiologi,nina.nevalainen@diagrad.umu.se
(författare)
Serotonergic nerve fibers in l-DOPA-derived dopamine release and dyskinesia
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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Elsevier,2014
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LIBRIS-ID:oai:DiVA.org:umu-84741
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84741URI
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https://doi.org/10.1016/j.neuroscience.2013.12.029DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The 5-HT (5-hydroxytryptamine) system has been assigned a key role in the development of 3,4-dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia, mainly due to 5-HT neuronal ability to decarboxylate l-DOPA into dopamine. Nevertheless, knowledge of l-DOPA-induced events that could lead to development of dyskinesias are limited and therefore the present work has evaluated (i) the role of the 5-HT system in l-DOPA-derived dopamine synthesis when dopamine neurons are present, (ii) l-DOPA-induced effects on striatal dopamine release and clearance, and on 5-HT nerve fiber density, and (iii) the behavioral outcome of altered 5-HT transmission in dyskinetic rats. Chronoamperometric recordings demonstrated attenuated striatal l-DOPA-derived dopamine release (∼30%) upon removal of 5-HT nerve fibers in intact animals. Interestingly, four weeks of daily l-DOPA treatment yielded similar-sized dopamine peak amplitudes in intact animals as found after a 5-HT-lesion. Moreover, chronic l-DOPA exposure attenuated striatal 5-HT nerve fiber density in the absence of dopamine nerve terminals. Furthermore, fluoxetine-induced altered 5-HT transmission blocked dyskinetic behavior via action on 5-HT1A receptors. Taken together, the results indicate a central role for the 5-HT system in l-DOPA-derived dopamine synthesis and in dyskinesia, and therefore potential l-DOPA-induced deterioration of 5-HT function might reduce l-DOPA efficacy as well as promote the upcoming of motor side effects.
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Af Bjerkén, SaraUmeå universitet,Histologi med cellbiologi(Swepub:umu)saaafn99
(författare)
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Gerhardt, G ADepartment of Anatomy, Neurobiology, and Neurology, University of Kentucky Medical Center, Lexington, KY, USA
(författare)
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Strömberg, IingridUmeå universitet,Histologi med cellbiologi(Swepub:umu)inst0001
(författare)
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Umeå universitetHistologi med cellbiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuroscience: Elsevier260, s. 73-860306-45221873-7544
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