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Genes Involved in E...
Genes Involved in Epithelial Differentiation and Development are Differentially Expressed in Oral and Genital Lichen Planus Epithelium Compared to Normal Epithelium
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- Danielsson, Karin (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Coates, Philip J (författare)
- Umeå universitet,Institutionen för odontologi
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- Ebrahimi, Majid (författare)
- Umeå universitet,Tandläkarutbildning
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- Nylander, Elisabet (författare)
- Umeå universitet,Dermatologi och venereologi
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- Wahlin, Ylva-Britt (författare)
- Umeå universitet,Institutionen för odontologi
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- Nylander, Karin (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Medical Journals Sweden AB, 2014
- 2014
- Engelska.
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 94:5, s. 526-530
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://www.medicalj...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Lichen planus (LP) is a chronic mucocutaneous disease with unknown cause. Patients with LP often have both oral and genital lesions, but these conditions are often considered as separate diseases and treated accordingly. To find out which genes are differently expressed in mucosal LP compared to normal mucosa and establish whether oral and genital LP are in fact the same disease, whole genome expression analysis was performed on epithelium from 13 patients diagnosed with oral and/or genital LP and normal controls. For confirmation of keratin 4 and corneodesmosin expression, quantitative reverse-transcription PCR and immunohistochemistry were used. Many genes involved in epithelial development and differentiation are differently expressed in epithelium from LP compared to normal epithelium. Several of the differentially expressed genes are common for oral and genital LP and the same biological processes are altered which supports the fact that oral and genital LP are manifestations of the same disease. The change in gene expression indicates that differentiation is altered leading to changes in the epithelial barrier.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- oral lichen planus
- genital lichen planus
- epithelial differentiation
- corneodesmosin
- keratin 4
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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