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CD4+CD25+ T cells f...
CD4+CD25+ T cells facilitate the induction of T cell anergy
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- Ermann, Joerg (författare)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Szanya, Veronika (författare)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Ford, Gregory S. (författare)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Paragas, Violette (författare)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Garrison Fathman, C. (författare)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Lejon, Kristina, 1967- (författare)
- UmanGenomics, Umestans Företagspark, Umeå, Sweden
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(creator_code:org_t)
- Rockville Pike, Bethesda, MD : The American Association of Immunologists, Inc. 2001
- 2001
- Engelska.
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Ingår i: Journal of Immunology. - Rockville Pike, Bethesda, MD : The American Association of Immunologists, Inc.. - 0022-1767 .- 1550-6606. ; 167:8, s. 4271-4275
- Relaterad länk:
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http://www.jimmunol....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- T cell anergy is characterized by the inability of the T cell to produce IL-2 and proliferate. It is reversible by the addition of exogenous IL-2. A similar state of unresponsiveness is observed when the proliferative response of murine CD4+CD25- T cells is suppressed in vitro by coactivated CD4+CD25+ T cells. We have developed a suppression system that uses beads coated with anti-CD3 and anti-CD28 Abs as surrogate APCs to study the interaction of CD4+CD25+ and CD4+CD25- T cells in vitro. CD4+CD25+ T cell-induced suppression, in this model, was not abrogated by blocking the B7-CTLA-4 pathway. When the CD4+CD25- T cells were separated from the CD4+CD25+ suppressor cells after 24 h of coactivation by the Ab-coated beads, the CD4+CD25- T cells were unable to proliferate or to produce IL-2 upon restimulation. The induction of this anergic phenotype in the CD4+CD25- T cells correlated with the up-regulated expression of the gene related to anergy in lymphocytes (GRAIL), a novel anergy-related gene that acts as a negative regulator of IL-2 transcription. This system constitutes a novel mechanism of anergy induction in the presence of costimulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- immunologi
- Immunology
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- art (ämneskategori)
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