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Sökning: onr:"swepub:oai:DiVA.org:umu-90857" > Four-Group Classifi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003747naa a2200409 4500
001oai:DiVA.org:umu-90857
003SwePub
008140701s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-908572 URI
0247 a https://doi.org/10.1161/CIRCIMAGING.113.0012752 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bang, Casper N.4 aut
2451 0a Four-Group Classification of Left Ventricular Hypertrophy Based on Ventricular Concentricity and Dilatation Identifies a Low-Risk Subset of Eccentric Hypertrophy in Hypertensive Patients
264 1c 2014
338 a print2 rdacarrier
520 a Background-Left ventricular hypertrophy (LVH; high LV mass [LVM]) is traditionally classified as concentric or eccentric based on LV relative wall thickness. We evaluated the prediction of subsequent adverse events in a new 4-group LVH classification based on LV dilatation (high LV end-diastolic volume [EDV] index) and concentricity (mass/end-diastolic volume [M/EDV](2/3)) in hypertensive patients. Methods and Results-In the Losartan Intervention for Endpoint Reduction (LIFE) echocardiography substudy, 939 hypertensive patients with measurable LVM at baseline were randomized to a mean of 4.8 years of losartan- or atenolol-based treatment. Patients with LVH (LVM/body surface area >= 116 and >= 96 g/m(2) in men and woman, respectively) were divided into 4 groups-concentric nondilated (increased M/EDV, normal EDV), eccentric dilated (increased EDV, normal M/EDV), concentric dilated (increased M/EDV and EDV), and eccentric nondilated (normal M/EDV and EDV)-and compared with patients with normal LVM. Time-varying LVH classes were tested for association with all-cause and cardiovascular mortality and a composite end point of myocardial infarction, stroke, heart failure, and cardiovascular death in multivariable Cox analyses. At baseline, the LVs were categorized as eccentric nondilated in 12%, eccentric dilated in 20%, concentric nondilated in 29%, concentric dilated in 14%, and normal LVM in 25%. Treatment changed the prevalence of 4 LVH groups to 23%, 4%, 5%, and 7%; 62% had normal LVM after 4 years. In time-varying Cox analyses, compared with normal LVM, those with eccentric dilated and both concentric nondilated and dilated LVH had increased risks of all-cause or cardiovascular mortality or the composite end point, whereas the eccentric nondilated group did not. Conclusions-Hypertensive patients with relatively mild LVH without either increased LV volume or concentricity have similar risk of all-cause mortality or cardiovascular events because hypertensive patients with normal LVM seem to be a low-risk group.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a hypertension
653 a hypertrophy
653 a left ventricular geometry
7001 a Gerdts, Eva4 aut
7001 a Aurigemma, Gerard P.4 aut
7001 a Boman, Kurtu Umeå universitet,Medicin4 aut0 (Swepub:umu)kubo0001
7001 a de Simone, Giovanni4 aut
7001 a Dahlof, Bjorn4 aut
7001 a Kober, Lars4 aut
7001 a Wachtell, Kristian4 aut
7001 a Devereux, Richard B.4 aut
7102 a Umeå universitetb Medicin4 org
7730 t Circulation Cardiovascular Imagingg 7:3, s. 422-429q 7:3<422-429x 1941-9651x 1942-0080
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-90857
8564 8u https://doi.org/10.1161/CIRCIMAGING.113.001275

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