Interaction with a phospholipid monolayer on a mercury electrode Multivariate analysis of impedance data

• Dioleyl phosphatidylcholine (DOPC) monolayer coated mercury electrodes were investigated with electrochemical impedance spectroscopy. The data from experiments with coated electrodes in contact with different electrolytes was analysed with principal component analysis and regression methods to characterise the significant features of the various impedance spectra. It is shown by combining multivariate analysis and electrochemical impedance spectroscopy that it is possible to differentiate between the various spectra from measurements in KCl, NaCl, CsCl, and LiCl, respectively. Some aspects of drug interaction, doxorubicin, with the monolayer are also discussed.

Nyckelord

Phospholipid monolayer

Impedence spectra

Biological membrane

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