onr:"swepub:oai:DiVA.org:umu-92148"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02820naa a2200289 4500 | |
| 001 | oai:DiVA.org:umu-92148 | |
| 003 | SwePub | |
| 008 | 140821s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-921482 URI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rosenquist, R4 aut |
| 245 | 1 0 | a Low rate of somatic hypermutations characterize progressive B-cell lymphomas. |
| 264 | 1 | c 1998 |
| 338 | a print2 rdacarrier | |
| 520 | a Immunoglobulin heavy (IgH) chain gene rearrangements were characterized in 40 samples from 15 patients with B-cell lymphomas at different time points during tumour progression. Using polymerase chain reaction (PCR) amplification and single strand conformation polymorphism (SSCP) analysis of variable heavy (VH) chain gene segments, we found that 6 cases displayed alterations in their IgH chain rearrangements at relapse. These alterations were mainly observed in follicular or transformed lymphomas, but no association to clinical features was found. Nucleotide sequence analysis revealed a low frequency of mutations in 3 cases, whereas 1 case displayed an extensive mutation rate in a compartment with transformed morphology at relapse. The mutations observed most probably resulted from somatic hypermutations. Further, the mutations were scattered randomly over the VH gene segment and no significant bias favouring amino acid substitutions was observed in 3 cases, suggesting that the tumour cells had not been subjected to antigen-driven selection. In 1 case, however, the mutation pattern indicated that the tumour cells had been affected by an antigen selection process. In the 2 remaining cases, the original V(H)DJ(H) rearrangement could no longer be detected by VH gene family specific PCR at relapse, but using primers specific for the framework region 2 or 3 altered rearrangements were demonstrated, implying that mutations had been introduced in framework region 1. However, the majority of the tumour cell clones analysed were relatively stable during tumour progression, which make them eligible for analysis of minimal residual disease using the VH gene regions as molecular markers. | |
| 700 | 1 | a Lindström, A4 aut |
| 700 | 1 | a Li, Aihongu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)liai0001 |
| 700 | 1 | a Roos, Göranu Umeå universitet,Patologi4 aut0 (Swepub:umu)goro0001 |
| 700 | 1 | a Lindh, Jacku Umeå universitet,Onkologi4 aut0 (Swepub:umu)jali0001 |
| 700 | 1 | a Holmberg, D4 aut |
| 710 | 2 | a Umeå universitetb Klinisk kemi4 org |
| 773 | 0 | t European Journal of Haematologyg 61:3, s. 164-72q 61:3<164-72x 0902-4441x 1600-0609 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92148 |
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