Family history of cancer as a risk factor for second malignancies after Hodgkin's lymphoma

This study estimated the risk of second primary malignancies after Hodgkin's lymphoma (HL) in relation to family history of cancer, age at diagnosis and latency, among 6946 patients treated for HL in Sweden in 1965–1995 identified through the Swedish Cancer Register (SCR). First-degree relatives (FDRs) to the HL patients and their malignancies were then ascertained together with their malignancies through the Multi-Generation Registry and SCR. The HL patient cohort was stratified on the number of FDRs with cancer, and standardised incidence ratios (SIRs) of developing SM were analysed. In the HL cohort, 781 SM were observed 1 year or longer after HL diagnosis. The risk for developing SM increased with the number of FDRs with cancer, SIRs being 2.26, 3.01, and 3.45 with 0, 1, or ≥2 FDRs with cancer, respectively. Hodgkin's lymphoma long-term survivors treated at a young age with a family history of cancer carry an increased risk for developing SM and may represent a subgroup where standardised screening for the most common cancer sites could be offered in a stringent surveillance programme.

Enblad, GunillaUppsala universitet,Enheten för onkologi(Swepub:uu)gunienbl (författare)
Tavelin, BjörnUmeå universitet,Onkologi(Swepub:umu)bjta0001 (författare)
Björkholm, MagnusKarolinska Institutet (författare)
Linderoth, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-jli (författare)
Lagerlöf, I (författare)
Merup, MatsKarolinska Institutet (författare)
Sender, Mark (författare)
Malmer, BeatriceUmeå universitet,Onkologi(Swepub:umu)bema0010 (författare)
Umeå universitetOnkologi (creator_code:org_t)

Ingår i:British Journal of Cancer: Springer Science and Business Media LLC98:5, s. 1001-10050007-09201532-1827

Av författaren/redakt...: Andersson, Anne, ...; Enblad, Gunilla; Tavelin, Björn; Björkholm, Magnu ...; Linderoth, Johan; Lagerlöf, I; visa fler...; Merup, Mats; Sender, Mark; Malmer, Beatrice; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Av lärosätet: Umeå universitet; Lunds universitet; Uppsala universitet; Karolinska Institutet

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