Sökning: onr:"swepub:oai:DiVA.org:umu-93568" > COBRA :
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05609naa a2200601 4500 | |
001 | oai:DiVA.org:umu-93568 | |
003 | SwePub | |
008 | 140925s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131467718 | |
009 | oai:DiVA.org:su-119135 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-935682 URI |
024 | 7 | a https://doi.org/10.1016/j.brainres.2014.09.0102 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1314677182 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1191352 URI |
040 | a (SwePub)umud (SwePub)kid (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nevalainen, Ninau Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)nine0001 |
245 | 1 0 | a COBRA :b A prospective multimodal imaging study of dopamine, brain structure and function, and cognition. |
264 | 1 | b Elsevier BV,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Cognitive decline is a characteristic feature of normal human aging. Previous work has demonstrated marked interindividual variability in onset and rate of decline. Such variability has been linked to factors such as maintenance of functional and structural brain integrity, genetics, and lifestyle. Still, few, if any, studies have combined a longitudinal design with repeated multimodal imaging and a comprehensive assessment of cognition as well as genetic and lifestyle factors. The present paper introduces the Cognition, Brain, and Aging (COBRA) study, in which cognitive performance and brain structure and function are measured in a cohort of 181 older adults aged 64 to 68 years at baseline. Participants will be followed longitudinally over a 10-year period, resulting in a total of three equally spaced measurement occasions. The measurement protocol at each occasion comprises a comprehensive set of behavioral and imaging measures. Cognitive performance is evaluated via computerized testing of working memory, episodic memory, perceptual speed, motor speed, implicit sequence learning, and vocabulary. Brain imaging is performed using positron emission tomography with [(11)C]-raclopride to assess dopamine D2/D3 receptor availability. Structural magnetic resonance imaging (MRI) is used for assessment of white and gray-matter integrity and cerebrovascular perfusion, and functional MRI maps brain activation during rest and active task conditions. Lifestyle descriptives are collected, and blood samples are obtained and stored for future evaluation. Here, we present selected results from the baseline assessment along with a discussion of sample characteristics and methodological considerations that determined the design of the study. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Aging | |
653 | a Cognitive decline | |
653 | a Striatum | |
653 | a Magnetic resonance imaging (MRI) | |
653 | a Positron emission tomography (PET) | |
653 | a [ 11C]-raclopride | |
700 | 1 | a Riklund, Katrineu Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)kaah0001 |
700 | 1 | a Andersson, Micaelu Umeå universitet,Fysiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)mian0001 |
700 | 1 | a Axelsson, Janu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)jaax0004 |
700 | 1 | a Ögren, Mattiasu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)maog0003 |
700 | 1 | a Lövdén, Mu Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
700 | 1 | a Lindenberger, Uu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany4 aut |
700 | 1 | a Bäckman, Lu Stockholms universitet,Karolinska Institutet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
700 | 1 | a Nyberg, Larsu Umeå universitet,Fysiologi,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)4 aut0 (Swepub:umu)lany0001 |
710 | 2 | a Umeå universitetb Institutionen för strålningsvetenskaper4 org |
773 | 0 | t Brain Researchd : Elsevier BVg 1612, s. 83-103q 1612<83-103x 0006-8993x 1872-6240 |
856 | 4 | u https://doi.org/10.1016/j.brainres.2014.09.010y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:749765/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.brainres.2014.09.010 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93568 |
856 | 4 8 | u https://doi.org/10.1016/j.brainres.2014.09.010 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131467718 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-119135 |
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