Sökning: onr:"swepub:oai:DiVA.org:umu-94171" > Insulin-like growth...
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000 | 04726naa a2200709 4500 | |
001 | oai:DiVA.org:umu-94171 | |
003 | SwePub | |
008 | 141006s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-941712 URI |
024 | 7 | a https://doi.org/10.1093/jnci/dju2182 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Cao, Yin4 aut |
245 | 1 0 | a Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival |
264 | c 2014-05-14 | |
264 | 1 | b Oxford University Press,c 2014 |
338 | a print2 rdacarrier | |
500 | a Errata JNCI-Journal of the National Cancer Institute (2014) 106 (6), dju085. DOI:10.1093/jnci/dju085 | |
520 | a BACKGROUND: The insulin-like growth factor (IGF) signaling pathway has been implicated in prostate cancer (PCa) initiation, but its role in progression remains unknown.METHODS: Among 5887 PCa patients (704 PCa deaths) of European ancestry from seven cohorts in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium, we conducted Cox kernel machine pathway analysis to evaluate whether 530 tagging single nucleotide polymorphisms (SNPs) in 26 IGF pathway-related genes were collectively associated with PCa mortality. We also conducted SNP-specific analysis using stratified Cox models adjusting for multiple testing. In 2424 patients (313 PCa deaths), we evaluated the association of prediagnostic circulating IGF1 and IGFBP3 levels and PCa mortality. All statistical tests were two-sided.RESULTS: The IGF signaling pathway was associated with PCa mortality (P = .03), and IGF2-AS and SSTR2 were the main contributors (both P = .04). In SNP-specific analysis, 36 SNPs were associated with PCa mortality with P-trend less than .05, but only three SNPs in the IGF2-AS remained statistically significant after gene-based corrections. Two were in linkage disequilibrium (r(2) = 1 for rs1004446 and rs3741211), whereas the third, rs4366464, was independent (r(2) = 0.03). The hazard ratios (HRs) per each additional risk allele were 1.19 (95% confidence interval [CI] = 1.06 to 1.34; P-trend = .003) for rs3741211 and 1.44 (95% CI = 1.20 to 1.73; P-trend < .001) for rs4366464. rs4366464 remained statistically significant after correction for all SNPs (P-trend.corr = .04). Prediagnostic IGF1 (HRhighest (vs lowest quartile) = 0.71; 95% CI = 0.48 to 1.04) and IGFBP3 (HR = 0.93; 95% Cl = 0.65 to 1.34) levels were not associated with PCa mortality.CONCLUSIONS: The IGF signaling pathway, primarily IGF2-AS and SSTR2 genes, may be important in PCa survival. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Lindström, Sara4 aut |
700 | 1 | a Schumacher, Fredrick4 aut |
700 | 1 | a Stevens, Victoria L.4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Berndt, Sonja I.4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Chamosa, Saioa4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Gapstur, Susan M.4 aut |
700 | 1 | a Gaziano, J. Michael4 aut |
700 | 1 | a Giovannucci, Edward L.4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Henderson, Brian4 aut |
700 | 1 | a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France4 aut0 (Swepub:umu)masmas97 |
700 | 1 | a Le Marchand, Loïc4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Rosner, Bernard4 aut |
700 | 1 | a Siddiq, Afshan4 aut |
700 | 1 | a Stampfer, Meir4 aut |
700 | 1 | a Stram, Daniel O.4 aut |
700 | 1 | a Tamimi, Rulla4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Willett, Walter C.4 aut |
700 | 1 | a Yeager, Meredith4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Hsing, Ann W.4 aut |
700 | 1 | a Pollak, Michael4 aut |
700 | 1 | a Lin, Xihong4 aut |
700 | 1 | a Ma, Jing4 aut |
710 | 2 | a Umeå universitetb Enheten för biobanksforskning4 org |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Pressg 106:5q 106:5x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/106/5/dju218/17985810/dju218.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-94171 |
856 | 4 8 | u https://doi.org/10.1093/jnci/dju218 |
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