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Combining phase and...
Combining phase and magnitude information for contrast agent quantification in dynamic contrast-enhanced MRI using statistical modeling
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- Brynolfsson, Patrik (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Yu, Jun, 1962- (författare)
- Umeå universitet,Institutionen för matematik och matematisk statistik,Mathematical Statistics
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- Wirestam, Ronnie (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Medical Radiation Physics
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- Karlsson, Mikael (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Garpebring, Anders, 1980- (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper,CJ Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands
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(creator_code:org_t)
- 2014-10-16
- 2015
- Engelska.
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Ingår i: Magnetic Resonance in Medicine. - : Wiley-Blackwell. - 0740-3194 .- 1522-2594. ; 74:4, s. 1156-1164
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Purpose: The purpose of this study was to investigate, using simulations, a method for improved contrast agent (CA) quantification in DCE-MRI.Methods: We developed a maximum likelihood estimator that combines the phase signal in the DCE-MRI image series with an additional CA estimate, e.g. the estimate obtained from magnitude data. A number of simulations were performed to investigate the ability of the estimator to reduce bias and noise in CA estimates. Noise levels ranging from that of a body coil to that of a dedicated head coil were investigated at both 1.5T and 3T.Results: Using the proposed method, the root mean squared error in the bolus peak was reduced from 2.24 to 0.11 mM in the vessels and 0.16 to 0.08 mM in the tumor rim for a noise level equivalent of a 12-channel head coil at 3T. No improvements were seen for tissues with small CA uptake, such as white matter.Conclusion: Phase information reduces errors in the estimated CA concentrations. A larger phase response from higher field strengths or higher CA concentrations yielded better results. Issues such as background phase drift need to be addressed before this method can be applied in vivo.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- dynamic contrast-enhanced MRI
- contrast agent quantification
- phase
- inverse problem
- inverse problem
- phase
- contrast agent quantification
- dynamic contrast-enhanced MRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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