Sökning: onr:"swepub:oai:DiVA.org:umu-95221" > FTO genetic variant...
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000 | 09264naa a2201657 4500 | |
001 | oai:DiVA.org:umu-95221 | |
003 | SwePub | |
008 | 141024s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:46b63485-4e48-43f0-9e01-b51126e6a655 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-952212 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddu4112 DOI |
024 | 7 | a https://lup.lub.lu.se/record/46152562 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Qi, Qibinu Albert Einstein Coll Med, Dept Epidemiol, Bronx, NY 10467 USA4 aut |
245 | 1 0 | a FTO genetic variants, dietary intake and body mass index :b insights from 177 330 individuals |
264 | c 2014-08-07 | |
264 | 1 | b Oxford University Press (OUP),c 2014 |
338 | a print2 rdacarrier | |
520 | a FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Kilpeläinen, Tuomas O4 aut |
700 | 1 | a Kristiansson, Katiu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-kka |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Smith, Caren E4 aut |
700 | 1 | a Sluijs, Ivonne4 aut |
700 | 1 | a Sonestedt, Emilyu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso |
700 | 1 | a Chu, Audrey Y4 aut |
700 | 1 | a Renström, Fridau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm |
700 | 1 | a Lin, Xiaochen4 aut |
700 | 1 | a Angquist, Lars H4 aut |
700 | 1 | a Huang, Jinyan4 aut |
700 | 1 | a Liu, Zhonghua4 aut |
700 | 1 | a Li, Yanping4 aut |
700 | 1 | a Asif Ali, Muhammad4 aut |
700 | 1 | a Xu, Min4 aut |
700 | 1 | a Ahluwalia, Tarunveer Singh4 aut |
700 | 1 | a Boer, Jolanda M A4 aut |
700 | 1 | a Chen, Peng4 aut |
700 | 1 | a Daimon, Makoto4 aut |
700 | 1 | a Eriksson, Johan4 aut |
700 | 1 | a Perola, Markusu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-mkp |
700 | 1 | a Friedlander, Yechiel4 aut |
700 | 1 | a Gao, Yu-Tang4 aut |
700 | 1 | a Heppe, Denise H M4 aut |
700 | 1 | a Holloway, John W4 aut |
700 | 1 | a Houston, Denise K4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Kim, Yu-Mi4 aut |
700 | 1 | a Laaksonen, Maarit A4 aut |
700 | 1 | a Jääskeläinen, Tiina4 aut |
700 | 1 | a Lee, Nanette R4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Lemaitre, Rozenn N4 aut |
700 | 1 | a Lu, Wei4 aut |
700 | 1 | a Luben, Robert N4 aut |
700 | 1 | a Manichaikul, Ani4 aut |
700 | 1 | a Männistö, Satu4 aut |
700 | 1 | a Marques-Vidal, Pedro4 aut |
700 | 1 | a Monda, Keri L4 aut |
700 | 1 | a Ngwa, Julius S4 aut |
700 | 1 | a Perusse, Louis4 aut |
700 | 1 | a van Rooij, Frank J A4 aut |
700 | 1 | a Xiang, Yong-Bing4 aut |
700 | 1 | a Wen, Wanqing4 aut |
700 | 1 | a Wojczynski, Mary K4 aut |
700 | 1 | a Zhu, Jingwen4 aut |
700 | 1 | a Borecki, Ingrid B4 aut |
700 | 1 | a Bouchard, Claude4 aut |
700 | 1 | a Cai, Qiuyin4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Dedoussis, George V4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Forouhi, Nita G4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Christiansen, Lene4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Johansson, Ingegerdu Umeå universitet,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003 |
700 | 1 | a Jørgensen, Torben4 aut |
700 | 1 | a Karasawa, Shigeru4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Kim, Mi-Kyung4 aut |
700 | 1 | a Kristiansson, Kati4 aut |
700 | 1 | a Li, Huaixing4 aut |
700 | 1 | a Lin, Xu4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Lohman, Kurt K4 aut |
700 | 1 | a Long, Jirong4 aut |
700 | 1 | a Mikkilä, Vera4 aut |
700 | 1 | a Mozaffarian, Dariush4 aut |
700 | 1 | a North, Kari4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Rissanen, Harri4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a van der Schouw, Yvonne T4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Carola Zillikens, M4 aut |
700 | 1 | a Franco, Oscar H4 aut |
700 | 1 | a Shyong Tai, E4 aut |
700 | 1 | a Ou Shu, Xiao4 aut |
700 | 1 | a Siscovick, David S4 aut |
700 | 1 | a Toft, Ulla4 aut |
700 | 1 | a Monique Verschuren, W M4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Witteman, Jacqueline C M4 aut |
700 | 1 | a Zheng, Wei4 aut |
700 | 1 | a Ridker, Paul M4 aut |
700 | 1 | a Kang, Jae H4 aut |
700 | 1 | a Liang, Liming4 aut |
700 | 1 | a Jensen, Majken K4 aut |
700 | 1 | a Curhan, Gary C4 aut |
700 | 1 | a Pasquale, Louis R4 aut |
700 | 1 | a Hunter, David J4 aut |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a Uusitupa, Matti4 aut |
700 | 1 | a Adrienne Cupples, L4 aut |
700 | 1 | a Rankinen, Tuomo4 aut |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Wang, Tao4 aut |
700 | 1 | a Chasman, Daniel I4 aut |
700 | 1 | a Franks, Paulu Lund University,Lunds universitet,Umeå universitet,Medicin,Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA; Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; Lund Univ, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmo, Sweden,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Sørensen, Thorkild I A4 aut |
700 | 1 | a Hu, Frank B4 aut |
700 | 1 | a Loos, Ruth J F4 aut |
700 | 1 | a Nettleton, Jennifer A4 aut |
700 | 1 | a Qi, Lu4 aut |
710 | 2 | a Albert Einstein Coll Med, Dept Epidemiol, Bronx, NY 10467 USAb Genomik, diabetes och endokrinologi4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:25, s. 6961-6972q 23:25<6961-6972x 0964-6906x 1460-2083 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/23/25/6961/13916787/ddu411.pdf |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25104851?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1093/hmg/ddu411y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-95221 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddu411 |
856 | 4 8 | u https://lup.lub.lu.se/record/4615256 |
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