Sökning: onr:"swepub:oai:DiVA.org:umu-96615" > Post-G WAS gene-env...
Fältnamn | Indikatorer | Metadata |
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000 | 04505naa a2200769 4500 | |
001 | oai:DiVA.org:umu-96615 | |
003 | SwePub | |
008 | 141124s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-966152 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddu2232 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Barrdahl, Myrto4 aut |
245 | 1 0 | a Post-G WAS gene-environment interplay in breast cancer :b results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women |
264 | c 2014-05-08 | |
264 | 1 | b Oxford University Press (OUP),c 2014 |
338 | a print2 rdacarrier | |
520 | a We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case-control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case-case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and SLC4A7-rs4973768 (P-interaction = 8.84 x 10(-4)) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and SLC4A7-rs4973768 that if further replicated could help our understanding in the etiology of BC. | |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Joshi, Amit D.4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Auer, Paul L.4 aut |
700 | 1 | a Gapstur, Susan M.4 aut |
700 | 1 | a Gaudet, Mia4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Henderson, Brian E.4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Schumacher, Fredrick R.4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Berg, Christine D.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Hoover, Robert N.4 aut |
700 | 1 | a Rudolph, Anja4 aut |
700 | 1 | a Ziegler, Regina G.4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Baglietto, Laura4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Hankinson, Susan E.4 aut |
700 | 1 | a Lindstroem, Sara4 aut |
700 | 1 | a Willet, Walter4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Buring, Julie E.4 aut |
700 | 1 | a Lee, I-Min4 aut |
700 | 1 | a Zhang, Shumin4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Cox, David G.4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Naccarati, Alessio4 aut |
700 | 1 | a Peeters, Petra H.4 aut |
700 | 1 | a Ramon Quiros, J.4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Prentice, Ross L.4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Campa, Daniele4 aut |
710 | 2 | a Umeå universitetb Kirurgi4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:19, s. 5260-5270q 23:19<5260-5270x 0964-6906x 1460-2083 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/23/19/5260/17260677/ddu223.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96615 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddu223 |
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