Sökning: onr:"swepub:oai:DiVA.org:umu-96800" >
Fat Mass and Obesit...
-
Benedict, ChristianUppsala universitet,Funktionell farmakologi
(författare)
Fat Mass and Obesity-Associated Gene (FTO) Is Linked to Higher Plasma Levels of the Hunger Hormone Ghrelin and Lower Serum Levels of the Satiety Hormone Leptin in Older Adults
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
-
2014-10-13
-
American Diabetes Association,2014
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-96800
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96800URI
-
https://doi.org/10.2337/db14-0470DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228726URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The mechanisms through which common polymorphisms in the fat mass and obesity-associated gene (FTO) drive the development of obesity in humans are poorly understood. Using cross-sectional data from 985 older people (50% females) who participated at age 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), circulating levels of ghrelin and leptin were measured after an overnight fast. In addition, subjects were genotyped for FTO rs17817449 (AA, n = 345 [35%]; AC/CA, n = 481 [48.8%]; CC, n = 159 [16.1%]). Linear regression analyses controlling for sex, selfreported physical activity level, fasting plasma glucose, and BMI were used. A positive relationship between the number of FTO C risk alleles and plasma ghrelin levels was found (P = 0.005; relative plasma ghrelin difference between CC and AA carriers = similar to 9%). In contrast, serum levels of the satiety-enhancing hormone leptin were inversely linked to the number of FTO C risk alleles (P = 0.001; relative serum leptin difference between CC and AA carriers = similar to 11%). These associations were also found when controlling for waist circumference. The present findings suggest that FTO may facilitate weight gain in humans by shifting the endocrine balance from the satiety hormone leptin toward the hunger-promoting hormone ghrelin.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Axelsson, TomasUppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär medicin(Swepub:uu)toaxe957
(författare)
-
Söderberg, StefanUmeå universitet,Kardiologi,Heart Centre(Swepub:umu)stso0001
(författare)
-
Larsson, AndersUppsala universitet,Biokemisk struktur och funktion,Clinical Chemistry(Swepub:uu)andlarss
(författare)
-
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(författare)
-
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(författare)
-
Schiöth, Helgi BUppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
(författare)
-
Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Diabetes: American Diabetes Association63:11, s. 3955-39590012-17971939-327X
Internetlänk
Hitta via bibliotek
-
Diabetes
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas