Sökning: onr:"swepub:oai:DiVA.org:umu-96817" > The 19q12 Bladder C...
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000 | 07224naa a2201513 4500 | |
001 | oai:DiVA.org:umu-96817 | |
003 | SwePub | |
008 | 141203s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:129986425 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-968172 URI |
024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-14-15312 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1299864252 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fu, Yi-Ping4 aut |
245 | 1 0 | a The 19q12 Bladder Cancer GWAS Signal :b Association with Cyclin E Function and Aggressive Disease |
264 | 1 | c 2014 |
338 | a print2 rdacarrier | |
520 | a A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein. We performed genetic fine-mapping analysis of the CCNE1 region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r(2) >= 0.7) associated with increased bladder cancer risk. From this group, we selected a functional promoter variant rs7257330, which showed strong allele-specific binding of nuclear proteins in several cell lines. In both GWASs, rs7257330 was associated only with aggressive bladder cancer, with a combined per-allele OR = 1.18 [95% confidence interval (CI), 1.09-1.27, P = 4.67 x 10(-5)] versus OR = 1.01 (95% CI, 0.93-1.10, P = 0.79) for nonaggressive disease, with P = 0.0015 for case-only analysis. Cyclin E protein expression analyzed in 265 bladder tumors was increased in aggressive tumors (P = 0.013) and, independently, with each rs7257330-A risk allele (P-trend = 0.024). Overexpression of recombinant cyclin E in cell lines caused significant acceleration of cell cycle. In conclusion, we defined the 19q12 signal as the first GWAS signal specific for aggressive bladder cancer. Molecular mechanisms of this genetic association may be related to cyclin E overexpression and alteration of cell cycle in carriers of CCNE1 risk variants. In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the CCNE1 variants could be useful for inclusion into bladder cancer risk prediction models. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
700 | 1 | a Kohaar, Indu4 aut |
700 | 1 | a Moore, Lee E.4 aut |
700 | 1 | a Lenz, Petra4 aut |
700 | 1 | a Figueroa, Jonine D.4 aut |
700 | 1 | a Tang, Wei4 aut |
700 | 1 | a Porter-Gill, Patricia4 aut |
700 | 1 | a Chatterjee, Nilanjan4 aut |
700 | 1 | a Scott-Johnson, Alexandra4 aut |
700 | 1 | a Garcia-Closas, Montserrat4 aut |
700 | 1 | a Muchmore, Brian4 aut |
700 | 1 | a Baris, Dalsu4 aut |
700 | 1 | a Paquin, Ashley4 aut |
700 | 1 | a Ylaya, Kris4 aut |
700 | 1 | a Schwenn, Molly4 aut |
700 | 1 | a Apolo, Andrea B.4 aut |
700 | 1 | a Karagas, Margaret R.4 aut |
700 | 1 | a Tarway, McAnthony4 aut |
700 | 1 | a Johnson, Alison4 aut |
700 | 1 | a Mumy, Adam4 aut |
700 | 1 | a Schned, Alan4 aut |
700 | 1 | a Guedez, Liliana4 aut |
700 | 1 | a Jones, Michael A.4 aut |
700 | 1 | a Kida, Masatoshi4 aut |
700 | 1 | a Hosain, G. M. Monawar4 aut |
700 | 1 | a Malats, Nuria4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Tardon, Adonina4 aut |
700 | 1 | a Serra, Consol4 aut |
700 | 1 | a Carrato, Alfredo4 aut |
700 | 1 | a Garcia-Closas, Reina4 aut |
700 | 1 | a Lloreta, Josep4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Purdue, Mark4 aut |
700 | 1 | a Andriole, Gerald L., Jr.4 aut |
700 | 1 | a Grubb, Robert L., III4 aut |
700 | 1 | a Black, Amanda4 aut |
700 | 1 | a Landi, Maria T.4 aut |
700 | 1 | a Caporaso, Neil E.4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Siddiq, Afshan4 aut |
700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi,Njurcancer4 aut0 (Swepub:umu)bolj0001 |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Krogh, Vittorio4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Prescott, Jennifer4 aut |
700 | 1 | a Chen, Constance4 aut |
700 | 1 | a De Vivo, Immaculata4 aut |
700 | 1 | a Govannucci, Edward4 aut |
700 | 1 | a Hunter, David4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Lindstrom, Sara4 aut |
700 | 1 | a Gapstur, Susan M.4 aut |
700 | 1 | a Jacobs, Eric J.4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Weinstein, Stephanie J.4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Hohensee, Chancellor4 aut |
700 | 1 | a Rodabough, Rebecca J.4 aut |
700 | 1 | a Cortessis, Victoria K.4 aut |
700 | 1 | a Conti, David V.4 aut |
700 | 1 | a Gago-Dominguez, Manuela4 aut |
700 | 1 | a Stern, Mariana C.4 aut |
700 | 1 | a Pike, Malcolm C.4 aut |
700 | 1 | a Van Den Berg, David4 aut |
700 | 1 | a Yuan, Jian-Min4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Cussenot, Olivier4 aut |
700 | 1 | a Cancel-Tassin, Geraldine4 aut |
700 | 1 | a Roupret, Morgan4 aut |
700 | 1 | a Comperat, Eva4 aut |
700 | 1 | a Porru, Stefano4 aut |
700 | 1 | a Carta, Angela4 aut |
700 | 1 | a Pavanello, Sofia4 aut |
700 | 1 | a Arici, Cecilia4 aut |
700 | 1 | a Mastrangelo, Giuseppe4 aut |
700 | 1 | a Grossman, H. Barton4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Deng, Xiang4 aut |
700 | 1 | a Chung, Charles C.4 aut |
700 | 1 | a Hutchinson, Amy4 aut |
700 | 1 | a Burdette, Laurie4 aut |
700 | 1 | a Wheeler, William4 aut |
700 | 1 | a Fraumeni, Joseph, Jr.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Hewitt, Stephen M.4 aut |
700 | 1 | a Silverman, Debra T.4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Prokunina-Olsson, Ludmila4 aut |
710 | 2 | a Umeå universitetb Urologi och andrologi4 org |
773 | 0 | t Cancer Researchg 74:20, s. 5808-5818q 74:20<5808-5818x 0008-5472x 1538-7445 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96817 |
856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-14-1531 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129986425 |
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