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Effect of subcutane...
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Goldkuhl, RenéeUppsala universitet,Försöksdjursvetenskap
(författare)
Effect of subcutaneous injection and oral voluntary ingestion of buprenorphine on post-operative serum corticosterone levels in male rats
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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2008-07-03
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S. Karger AG,2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-102299
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102299URI
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https://doi.org/10.1159/000142372DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: Adequate peri-operative analgesia may reduce post-operative stress response and improve recovery in laboratory animals. We have established a method involving repeated automated blood sampling, allowing quantification of serum corticosterone levels in rats for stress assessment without stress-inducing handling or restraint. In the present study, the effects of the commonly used route of buprenorphine administration (0.05 mg/kg injected subcutaneously) were compared with oral administration (0.4 mg/kg mixed with Nutella and orally administered by voluntary ingestion) in male Sprague-Dawley rats. METHODS: A catheter was placed in the jugular vein and attached to an Accusampler for automated blood sampling. During 96 h after surgery, blood was collected at specified time points. Pre- and post-operative body weights and water consumption were registered. RESULTS: Buprenorphine significantly suppressed levels of circulating corticosterone after the oral but not after the subcutaneous treatment. Both buprenorphine treatments had a positive impact on maintenance of body weight and water consumption, compared to the control group that received no buprenorphine. CONCLUSION: The present investigation suggests that oral voluntary ingestion ad libitum is an efficacious, convenient and non-invasive way of administering peri-operative buprenorphine to rats, as judged by corticosteroid response and effects on body weight and water consumption.
Ämnesord och genrebeteckningar
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Surgical stress
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Analgesia
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Rats
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Carlsson, Hans-ErikUppsala universitet,Försöksdjursvetenskap
(författare)
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Hau, JannUppsala universitet,Försöksdjursvetenskap
(författare)
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Abelson, KlasUppsala universitet,Försöksdjursvetenskap
(författare)
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Uppsala universitetFörsöksdjursvetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Surgical Research: S. Karger AG41:3, s. 272-2780014-312X1421-9921
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