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Sökning: onr:"swepub:oai:DiVA.org:uu-102855" > Greater reduction o...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004666naa a2200577 4500
001oai:DiVA.org:uu-102855
003SwePub
008090512s2008 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:ebe8137c-3a9a-4219-9e15-7b5f2a127b90
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1028552 URI
0247 a https://doi.org/10.1160/TH08-05-03132 DOI
0247 a https://lup.lub.lu.se/record/12848472 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Braun, Oscaru Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kard-oos
2451 0a Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease
264 1c 2008
338 a print2 rdacarrier
520 a Prasugrel, a novel P2Y(12) ADP-receptor antagonist, has been reported to achieve greater inhibition of platelet aggregation compared to clopidogrel as assessed by light transmission aggregometry. It was the objective of this study to investigate the effect of prasugrel on alternative markers of platelet activation in comparison to a high loading dose and the approved maintenance dose of clopidogrel. One hundred ten aspirin-treated patients with stable coronary artery disease were randomized to a loading dose (LD, day 1)/ maintenance dose (MD, days 2-29) of prasugrel 60 mg/10 mg or clopidogrel 600 mg/75 mg. Platelet activation markers were analyzed by whole blood flow cytometry pre-dose and at 2 and 24 hours after LD and pre-dose at 14 and 29 days. After stimulation with 20 muM ADP, 2 hours after LD, significantly lower expression of activated GPIIb/IIIa (4.3 vs. 21.8 [mean fluorescent intensity (MFI)], p < 0.001) and P-selectin (2.0 vs. 11.7 MFI, p < 0.001) along with decreased formation of platelet-monocyte aggregates (16.4% vs. 29.6% positive cells, p < 0.001) was observed with prasugrel versus clopidogrel. All these effects were maintained through 24 hours and during the MD period. In conclusion, prasugrel 60 mg LD and 10 mg MD inhibit several markers of platelet activation and the formation of platelet-monocyte aggregates more effectively than a 600 mg LD and 75 mg MD of clopidogrel. Attenuated platelet aggregation and reduced expression of platelet pro-coagulant and pro-inflammatory markers with prasugrel suggest the potential to reduce cardiovascular events both in the acute setting and in long-term treatment.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a CAD
653 a thienopyridines
653 a platelet markers
653 a tissue factor
653 a flow cytometry
653 a MEDICINE
653 a MEDICIN
653 a flow cytometry
653 a tissue factor
653 a platelet markers
653 a CAD
653 a thienopyridines
7001 a Johnell, Matildau Uppsala universitet,Institutionen för medicinska vetenskaper4 aut
7001 a Varenhorst, Christophu Uppsala universitet,Institutionen för medicinska vetenskaper,UCR4 aut0 (Swepub:uu)chrva923
7001 a James, Stefan,d 1964-u Uppsala universitet,Institutionen för medicinska vetenskaper,UCR4 aut0 (Swepub:uu)stjam367
7001 a Brandt, John T.4 aut
7001 a Jakubowski, Joseph A.4 aut
7001 a Winters, Kenneth J.4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Institutionen för medicinska vetenskaper,UCR4 aut0 (Swepub:uu)larswall
7001 a Erlinge, Davidu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kard-der
7001 a Siegbahn, Agneta,d 1947-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)agsie424
7102 a Kardiologib Sektion II4 org
7730 t Thrombosis and Haemostasisg 100:4, s. 626-633q 100:4<626-633x 0340-6245x 2567-689X
8564 u http://dx.doi.org/10.1160/TH08-05-0313y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102855
8564 8u https://doi.org/10.1160/TH08-05-0313
8564 8u https://lup.lub.lu.se/record/1284847

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