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A single nucleotide...
A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function
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- Brändström, Helena (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Stiger, Fredrik (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Kahan, Thomas (författare)
- Karolinska Institutet
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Kindmark, Andreas (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 293:1, s. 13-17
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor receptor family, and has previously been shown to regulate bone mass by inhibiting osteoclast differentiation and activation. Recent evidence indicates that OPG also plays a role in the vascular system, since ablation of the OPG gene in mice results in calcification of the aorta and renal arteries, and association has been found between serum levels of OPG and cardiovascular mortality. This study presents a novel single nucleotide polymorphism, a T/C transition located 129 bp upstream the TATA-box of the human OPG gene, detected by sequence analysis. The OPG genotype was determined by restriction fragment length polymorphism in a cohort consisting of 59 healthy subjects. The intima-media thickness (IMT) in the common carotid artery and maximal post-ischemic forearm blood flow (FBF) were investigated. Subjects with the CC genotype showed a significantly increased IMT (p<0.05) and a concommitantly reduced maximal FBF (p<0.01) as compared to those with the T allele. Thus, our results show that the polymorphism in the promoter region of OPG is associated with both vascular morphology and function in apparently healthy subjects.
Nyckelord
- Animals
- Base Sequence
- Carotid Artery; Common/physiology/ultrasonography
- DNA Primers
- Forearm/*blood supply
- Glycoproteins/deficiency/*genetics
- Humans
- Mice
- Mice; Knockout
- Muscle; Smooth; Vascular/*physiology
- Osteoprotegerin
- Polymerase Chain Reaction
- Polymorphism; Genetic
- Polymorphism; Single Nucleotide
- Promoter Regions (Genetics)
- Receptors; Cytoplasmic and Nuclear/deficiency/*genetics
- Receptors; Tumor Necrosis Factor/antagonists & inhibitors
- Reference Values
- Regional Blood Flow
- Sweden
- Tunica Intima/physiology/ultrasonography
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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