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Quantitative renal ...
Quantitative renal cortical perfusion in human subjects with magnetic resonance imaging using iron-oxide nanoparticles: influence of T1 shortening
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- Morell, Arvid, 1973- (författare)
- Uppsala universitet,Enheten för radiologi
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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- Schoenberg, Stefan (författare)
- University of Heidelberg, Institute of Clinical Radiology and Nuclear Medicine
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- Abildgaard, Andreas (författare)
- Rikshospitalet University Hospital, Department of Radiology
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- Bock, Michael (författare)
- German Cancer Research Center (DKFZ), Department of Medical Physics in Radiology
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- Bjørnerud, Atle (författare)
- Uppsala universitet,Enheten för radiologi
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(creator_code:org_t)
- 2008-10-01
- 2008
- Engelska.
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 49:8, s. 955-62
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Using conventional contrast agents, the technique of quantitative perfusion by observing the transport of a bolus with magnetic resonance imaging (MRI) is limited to the brain due to extravascular leakage. PURPOSE: To perform quantitative perfusion measurements in humans with an intravascular contrast agent, and to estimate the influence of the T1 relaxivity of the contrast agent on the first-pass response. MATERIAL AND METHODS: Renal cortical perfusion was measured quantitatively in six patients with unilateral renal artery stenosis using a rapid gradient double-echo sequence in combination with an intravenous bolus injection of NC100150 Injection, an intravascular contrast agent based on iron-oxide nanoparticles. The influence of T1 relaxivity was measured by comparing perfusion results based on single- and double-echo data. RESULTS: The mean values of cortical blood flow, cortical blood volume, and mean transit time in the normal kidneys were measured to 339+/-60 ml/min/100 g, 41+/-8 ml/100 g, and 7.3+/-1.0 s, respectively, based on double-echo data. The corresponding results based on single-echo data, which are not compensated for the T1 relaxivity, were 254+/-47 ml/min/100 g, 27+/-3 ml/100 g, and 6+/-1.2 s, respectively. CONCLUSION: The use of a double-echo sequence enabled elimination of confounding T1 effects and consequent systematic underestimation of the perfusion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Radiology
- Radiologi
- Radiology
- Radiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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