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TGF-beta signaling ...
TGF-beta signaling from a three-dimensional perspective : insight into selection of partners
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- Souchelnytskyi, Serhiy (författare)
- Karolinska Institutet,Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Moustakas, Aristidis (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Heldin, Carl-Henrik (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Trends in Cell Biolology. - 0962-8924 .- 1879-3088. ; 12:7, s. 304-307
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Members of the transforming growth factor beta (TGF-beta) family, which include TGF-beta s, activins and bone morphogenetic proteins (BMPs), are potent regulators of cell proliferation, differentiation, migration and apoptosis. They act through binding to and activating serine/threonine kinase receptors on the cell surface and triggering intracellular signaling pathways in which Smad proteins have essential roles. Here, we discuss recent structure-based studies of TGF-beta s and BMPs, their receptors, and of Smad proteins, which have unravelled insights into ligand specificity, receptor and Smad activation, as well as new features of Smads as phosphoserine-binding entities.
Nyckelord
- Animals
- Bone Morphogenetic Proteins/chemistry/physiology
- Crystallography; X-Ray
- DNA-Binding Proteins/chemistry/physiology
- Humans
- Models; Molecular
- Protein Conformation
- Signal Transduction
- Smad Proteins
- Trans-Activators/chemistry/physiology
- Transforming Growth Factor beta/*chemistry/physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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