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Acute effects of He...
Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse
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- Henriksnäs, Johanna (författare)
- Uppsala universitet,Integrativ Fysiologi
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- Atuma, Christer (författare)
- Uppsala universitet,Integrativ Fysiologi
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- Phillipson, Mia (författare)
- Uppsala universitet,Integrativ Fysiologi
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- Sandler, Stellan (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Engstrand, Lars (författare)
- Karolinska Institutet
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- Holm, Lena (författare)
- Uppsala universitet,Integrativ Fysiologi
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(creator_code:org_t)
- Baishideng Publishing Group Inc. 2009
- 2009
- Engelska.
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Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 15:2, s. 219-225
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- AIM: To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (HPE).METHODS: The stomachs of isoflurane-anesthetized mice were exteriorized, and the mucosal surface exposed. Blood flow was measured with the laser-Doppler technique, and systemic arterial blood pressure monitored. C57BL/6 mice were exposed to water extract produced from H pylori strain 88-23. To investigate the role of a nerve- or iNOS-mediated pathway, we used intraluminal lidocaine and iNOS-/- mice. Blood flow response to the endogenous nitric oxide synthase inhibitor asymmetric dimethyl arginine (ADMA) was also assessed.RESULTS: In wild-type mice, HPE decreased mucosal blood flow by approximately 30%. This reduction was abolished in iNOS-deficient mice, and by pre-treatment with lidocaine. Luminally applied ADMA resulted in reduction in blood flow similar to that observed in wild-type mice exposed to HPE.CONCLUSION: A H pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways.
Nyckelord
- Gastric mucosal blood flow
- In vivo
- Laser-Doppler flowmetry
- Mice
- Helicobacter pylori
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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