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Embolization of exp...
Embolization of experimental wide-necked aneurysms with iodine-containing polyvinyl alcohol solubilized in a low-angiotoxicity solvent
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Dudeck, O. (författare)
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Jordan, O. (författare)
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Hoffmann, K. T. (författare)
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Okuducu, A. F. (författare)
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Husmann, I. (författare)
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Kreuzer-Nagy, T. (författare)
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Tesmer, K. (författare)
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Podrabsky, P. (författare)
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Bruhn, H. (författare)
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- Hilborn, Jöns (författare)
- Uppsala universitet,Polymerkemi
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Rüfenacht, D. A. (författare)
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Doelker, E. (författare)
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Felix, R. (författare)
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: American Journal of Neuroradiology. - 0195-6108 .- 1936-959X. ; 27:9, s. 1849-1855
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- BACKGROUND AND PURPOSE: To evaluate the ready-to-use iodine-containing polyvinyl alcohol (I-PVA) dissolved in the low angiotoxic solvent N-methyl pyrrolidone (NMP) for embolization of porcine wide-necked aneurysms. METHODS: Fourteen broad-based carotid sidewall aneurysms were surgically constructed in 7 swine. I-PVA (40%) in NMP was injected under temporary balloon occlusion bridging the aneurysm neck. After 4 weeks, follow-up angiography, multisection CT angiography (MSCTA), and 3T MR imaging including MR angiography (MRA) sequences were performed. Afterward, harvested aneurysms were investigated histopathologically. RESULTS: The liquid embolic was well visible under fluoroscopy and displayed a favorable precipitation pattern, allowing for controlled polymer delivery. Ten aneurysms (71%) were initially completely occluded, whereas in 1 aneurysm, a minimal polymer leakage was observed. The other 4 aneurysms (29%) were almost completely occluded. One animal suffered a lethal rebleeding from the anastomosis after uneventful embolization. Aneurysms embolized with I-PVA could be discriminated well from the parent artery without beam-hardening artifacts on MSCTA, and no susceptibility artifacts were encountered on MR imaging. Histologic examination revealed all aneurysms covered with a membrane of fibroblasts and an endothelial cell layer while a moderate intraaneurysmal inflammatory response to the polymer was observed. CONCLUSION: I-PVA dissolved in NMP has proved its effectiveness for the embolization of experimental wide-necked aneurysms. This precipitating liquid embolic offers several interesting features in that it needs no preparation before use and no radiopaque admixtures, the latter allowing for artifact-free evaluation of treated aneurysms with MSCTA and MRA. Moreover, it uses NMP as a solvent, which has only a low angiotoxicity.
Ämnesord
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
Nyckelord
- Inorganic chemistry
- Oorganisk kemi
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- art (ämneskategori)
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Dudeck, O.
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Jordan, O.
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Hoffmann, K. T.
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Okuducu, A. F.
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Husmann, I.
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Kreuzer-Nagy, T.
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visa fler...
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Tesmer, K.
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Podrabsky, P.
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Bruhn, H.
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Hilborn, Jöns
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Rüfenacht, D. A.
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Doelker, E.
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Felix, R.
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visa färre...
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Uppsala universitet