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HIV-1 reverse trans...
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Neumüller, M
(författare)
HIV-1 reverse transcriptase inhibiting antibody titer in serum : relation to disease progression and to core-antibody levels.
- Artikel/kapitelEngelska1992
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Wiley,1992
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LIBRIS-ID:oai:DiVA.org:uu-104579
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104579URI
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https://doi.org/10.1002/jmv.1890360410DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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A new assay for detecting inhibition of reverse transcriptase activity (the RT-i REA) was developed. This assay was standardized for screening serum samples for reverse transcriptase inhibiting antibodies (RT-iAb). High specificity (100%) and sensitivity (greater than 98%) were achieved with samples from HIV-negative individuals and HIV-infected individuals. The RT-i REA was also used in a study of the titers of RT-iAb in serum samples obtained from 33 HIV-infected homosexual men. The results confirmed the relation between decreasing RT-iAb levels and progression to late stages of the disease. Furthermore, a falling RT-iAb titer was observed in 14 of 15 individuals experiencing periods of severe clinical symptoms attributed to HIV-activity. In 7 of the patients the decline in RT-iAb titer began prior to severe clinical symptoms. The fall in RT-iAb titer also correlated with a reduction in core Ab level. The core Ab level has previously been reported to be a disease progression marker with considerable prognostic value. However, whereas all patients were positive for RT-iAb, 8 of the 33 patients did not have detectable core Ab. The use of RT-iAb titer as a marker of disease progression is discussed.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Karlsson, A
(författare)
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Lennerstrand, Johan
(författare)
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Källander, C F
(författare)
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Sandström, E
(författare)
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Holmberg, V
(författare)
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Gronowitz, J S
(författare)
Sammanhörande titlar
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Ingår i:Journal of Medical Virology: Wiley36:4, s. 283-2910146-66151096-9071
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