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Assessment of lipid...
Assessment of lipids in skeletal muscle by high-resolution spectroscopic imaging using fat as the internal standard : comparison with water referenced spectroscopy
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- Weis, Jan (författare)
- Uppsala universitet,Enheten för radiologi,Ahlström
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- Johansson, Lars (författare)
- Uppsala universitet,Enheten för radiologi
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- Ortiz-Nieto, Francisco (författare)
- Uppsala universitet,Enheten för radiologi,Ahlström
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Enheten för radiologi,Ahlström
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 59:6, s. 1259-1265
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The main purpose of the study was to compare proton (1H) single-voxel MR spectroscopy (MRS) with high-spatial-resolution spectroscopic imaging (MRSI) to determine the lipid content in human skeletal muscle. Unsuppressed water line was used as a concentration reference in the processing of single-voxel spectra. The spectrum from yellow bone marrow with a 100% fat content and probe with the vegetable oil served as internal and external reference for high-spatial-resolution MRSI, respectively. Very good correlation was found between lipid concentrations measured by water referenced single-voxel MRS and high-spatial-resolution MRSI with yellow bone marrow as the internal standard. Excellent correlation was found between total lipid concentrations estimated by high-spatial-resolution MRSI with vegetable oil as the external fat standard and yellow bone marrow as the internal reference. From comparison of single-voxel MRS and MRSI approaches, it follows that relaxation correction of the reference water and methylene fat line is inevitable in processing the standard single-voxel spectra. The high-resolution MRSI approach is recommended to avoid the problem of relaxation corrections and enables using vegetable oil as the external fat standard.
Nyckelord
- MR spectroscopy
- spectroscopic imaging
- muscular lipids
- quantitation
- external and internal fat reference
- relaxation corrections
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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