Sökning: onr:"swepub:oai:DiVA.org:uu-107272" > Lower expression le...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03897naa a2200481 4500 | |
001 | oai:DiVA.org:uu-107272 | |
003 | SwePub | |
008 | 090803s2010 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:120918534 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1072722 URI |
024 | 7 | a https://doi.org/10.1002/art.274172 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1209185342 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kristjánsdóttir, Helga,d 1966-u Uppsala universitet,Medicinsk genetik,Genetics of inflammatory diseases4 aut0 (Swepub:uu)helkr245 |
245 | 1 0 | a Lower expression levels of the programmed death 1 receptor on CD4+CD25+ T cells and correlation with the PD-1.3A genotype in patients with systemic lupus erythematosus |
264 | c 2010-02-22 | |
264 | 1 | b Wiley,c 2010 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE.: A genetic polymorphism, PD1.3A, in the PDCD1 gene encoding the co-inhibitory immunoreceptor PD-1, has been associated with SLE. The aim of the study was to assess PD-1 receptor expression in SLE patients, relatives and controls and correlate with PD-1.3A. METHODS.: Icelandic and Swedish SLE patients, relatives and controls were studied. PBMCs were stimulated with alphaCD3/CD28 and PD-1 expression analyzed by flow cytometry. PD-1.3A/G genotyping was performed by PCR-RFLP. RESULTS: I. PD-1 expression on PBMCs was induced after stimulation, by 2.1-fold in SLE patients, 3.1-fold in relatives and 5.1-fold in controls.II. The frequency of PD-1+ cells was significantly lower in SLE patients compared to relatives and controls. PD-1 expression on PD-1+ cells was significantly lower in SLE patients and relatives.III. PD-1 expression on CD4+CD25+ T cells was significantly lower in SLE patients and relatives.IV. PD-1 expression was significantly higher on CD25(high) compared to CD25(intermediate) and (low) cells.V. PD-1 expression on CD25(high) and CD25(intermediate) cells was significantly lower in SLE patients compared to controls.VI. PD-1 was expressed on both FoxP3- and FoxP3+ cells.VII. Lower PD-1 expression was significantly correlated with the PD-1.3A/G genotype. CONCLUSION.: The study demonstrates significantly lower PD-1 receptor expression in SLE patients and relatives and a significant correlation of lower PD-1 expression with the PD-1.3A allele. We conclude that PD-1.3A may be contributory to abnormalities in PD-1 receptor expression on CD4+CD25+ T-cells in SLE, providing support for an important role for the PD-1 pathway in SLE and possibly other autoimmune diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a SLE | |
653 | a PD-1.3A | |
653 | a self-tolerance | |
653 | a Immunology | |
653 | a Immunologi | |
653 | a Immunologi | |
653 | a Immunology | |
700 | 1 | a Steinsson, Kristjan4 aut |
700 | 1 | a Gunnarsson, Ivau Karolinska Institutet4 aut |
700 | 1 | a Gröndal, Gerdur4 aut |
700 | 1 | a Erlendsson, Kristjan4 aut |
700 | 1 | a Alarcón-Riquelme, Marta E.u Uppsala universitet,Medicinsk genetik4 aut |
710 | 2 | a Uppsala universitetb Medicinsk genetik4 org |
773 | 0 | t Arthritis and Rheumatismd : Wileyg 62:6, s. 1702-1711q 62:6<1702-1711x 0004-3591x 1529-0131 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.27417 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107272 |
856 | 4 8 | u https://doi.org/10.1002/art.27417 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120918534 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy