Sökning: onr:"swepub:oai:DiVA.org:uu-107920" > Aromatase gene (CYP...
Fältnamn | Indikatorer | Metadata |
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000 | 03985naa a2200469 4500 | |
001 | oai:DiVA.org:uu-107920 | |
003 | SwePub | |
008 | 090831s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:118766045 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1079202 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1187660452 URI |
024 | 7 | a https://doi.org/10.1016/S1472-6483(10)60009-02 DOI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Altmäe, Signeu Karolinska Institutet4 aut |
245 | 1 0 | a Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome :b a preliminary report |
264 | 1 | c 2009 |
338 | a print2 rdacarrier | |
520 | a Progress has been made towards ascertaining the genetic predictors of ovarian stimulation in IVF. Aromatase cytochrome P450, encoded by the CYP19A1 gene, catalyses a key step in ovarian oestrogen biosynthesis. Hence, the aromatase gene is an attractive candidate for genetic studies. This study aimed to examine the genetic influences of CYP19A1 TCT trinucleotide insertion/deletion (Ins/Del) and (TTTA)(n) microsatellite intronic polymorphisms on ovarian stimulation outcome and aetiology of female infertility. IVF patients (n = 152) underwent ovarian stimulation according to recombinant FSH and gonadotrophin releasing hormone antagonist protocol. Del/Del homozygous patients with shorter TTTA repeats exhibited decreased ovarian FSH sensitivity in ovarian stimulation, which may reflect variations in aromatase gene expression during early antral follicle development. Accordingly, this study demonstrates correlations between Del allele and shorter (TTTA)(n) repeat sizes with smaller ovaries (r = -0.70, P = 0.047) and fewer antral follicles (r = 0.21, P = 0.018) on days 3-5 of spontaneous menstrual cycle, respectively. Furthermore, Del variation linked with low-repeat-number (TTTA)(n) alleles are involved in enhanced genetic susceptibility to unexplained infertility (adjusted OR = 4.33, P = 0.039) and endometriosis (r = -0.88, P = 0.026), which corroborates evidence on the overlapping patient profiles of ovarian dysfunction in both types of female infertility. | |
653 | a aromatase | |
653 | a female infertility | |
653 | a IVF | |
653 | a ovarian stimulation | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Haller, Kadriu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut |
700 | 1 | a Peters, Maireu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut |
700 | 1 | a Saare, Merliu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut |
700 | 1 | a Hovatta, Outiu Karolinska Institutet4 aut |
700 | 1 | a Stavreus-Evers, Anneliu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)annst384 |
700 | 1 | a Velthut, Agneu Nova Vita Clinic, Centre for Infertility Treament and Medical Genetics, Estonia4 aut |
700 | 1 | a Karro, Helleu Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 aut |
700 | 1 | a Metspalu, Andresu Dept of Biotechnolgy, Institute of Molecular and Cell Biology, Estonian Genome Foundation, University of Tartu, Estonia4 aut |
700 | 1 | a Salumets, Andresu Dept of Biotechnolgy, Institute of Molecular and Cell Biology, Estonian Genome Foundation, University of Tartu, Estonia4 aut |
710 | 2 | a Karolinska Institutetb Dep of Obstetrics and Gynaecology, University of Tartu, Estonia4 org |
773 | 0 | t Reproductive BioMedicine Onlineg 18:5, s. 651-657q 18:5<651-657x 1472-6483x 1472-6491 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107920 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118766045 |
856 | 4 8 | u https://doi.org/10.1016/S1472-6483(10)60009-0 |
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