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Plasmacytoid DC pro...
Plasmacytoid DC promote priming of autoimmune Th17 cells and EAE
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- Isaksson, Magnus (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Lobell / Autoimmuna sjukdomar, Autoimmunity
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- Ardesjö, Brita (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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- Rönnblom, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Systemisk Autoimmunitet
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- Kämpe, Olle (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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Lassmann, Hans (författare)
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- Eloranta, Maija-Leena (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Systemisk Autoimmunitet
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- Lobell, Anna (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Lobell / Autoimmuna sjukdomar, Autoimmunity
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(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 39:10, s. 2925-2935
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- EAE, an animal model for MS, is a Th17 and Th1-cell-mediated autoimmune disease, but the mechanisms leading to priming of encephalitogenic T cells in autoimmune neuroinflammation are poorly understood. To investigate the role of plasmacytoid DC (pDC) in the initiation of autoimmune Th17- and Th1-cell responses and EAE, we depleted pDC with anti-pDC Ag-1 (anti-PDCA1) mAb prior to immunization of C57BL/6 mice with myelin oligodendrocyte glycoprotein (MOG). pDC-depleted mice developed less severe clinical and histopathological signs of EAE than control mice, which demonstrates a promoting role for pDC in the initiation of EAE. The levels of type I IFN were much lower in the sera from anti-PDCA1-treated mice. However, neutralization of type I IFN ameliorated the early phase of EAE but did not alter the severity of disease. Thus, only a minor part of the EAE-promoting effect of pDC appears to be mediated by IFN-alpha/beta secretion. The numbers of MOG-specific Th17 cells, but not Th1 cells, were lower in spleen from anti-PDCA1-treated mice compared with controls. In contrast, pDC depletion a week after MOG immunization resulted in more severe clinical signs of EAE. In conclusion, we demonstrate that pDC promote initiation of MOG-induced Th17-cell responses and EAE.
Nyckelord
- Autoimmunity
- DC
- EAE/MS
- T cells
- Type I IFN
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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